Magnesemia terapeutica alcanzada en mujeres con Preeclampsia severa atendidas en el Hospital Vicente Corral Moscoso Cuenca, enero – diciembre del 2014

Abstract

Objective Determine the percentage of pregnant women with severe preeclampsia that have subtherapetic magnesemia after the administration of 4 grams as impregnation and 1 gram/hour as maintenance of magnesium sulftate, in the service of Obstetrics of the Hospital Vicente Corral Moscoso, Cuenca-Ecuador during 2014. Materials and methods Descriptive study involved all women with severe pre-eclampsia who received magnesium sulfate according with Zuspan scheme to prevent eclampsia and signed informed consent. Patients with convulsions and kidney or liver failure were excluded. Data were collected through a questionnaire about socio-demographic variables, medical history, laboratory tests and signs of intoxication at 4 and 24 hours after initiation of treatment. The analysis was done using the program SPSS version 15. Results 108 cases were analyzed, there were no missing data. The average magnesium levels were 4.47 ± 1.69 mg/dl at 4 hours and 4.34 ± 1.54 mg/dl at 24 hours. The 69.4% had subtherapeutic levels at 4 hours and the 75.9% at 24. No patient had seizures. There was a case of intoxication that improved after the temporary de-crease of maintenance dose. Fisher test showed a significant difference between the magnesemia at 4 hours and nutritional status, p = 0.023; but not at 24 hours, p = 0.101. Conclusion 69.4% of women in this study after 4 hours and 75.9% at 24 hours showed sub-therapeutic levels of magnesium