Please use this identifier to cite or link to this item: http://dspace.ucuenca.edu.ec/handle/123456789/22008
Title: Fabrication of 3D bioactive ceramic scaffolds by robocasting
Authors: Andrade Cabrera, Santiago Patrico
Abdalla, A
Vanegas Peralta, Pablo Fernando
Keywords: Biomaterials
Bioreactor
Bone tissue engineering
Flexible scaffolds
Robocasting
Tricalcium phosphate
Issue Date: 29-Oct-2014
metadata.dc.ucuenca.embargoend: 1-Jan-2022
Publisher: SPRINGER VERLAG
metadata.dc.description.city: 
Paraná
metadata.dc.type: Article
Abstract: 
Tricalcium phosphate ceramics are bioactive and osteoconductive biomaterials that support cellular functions and can develop appropriate mechanical characteristics for bone tissue engineering. Fast prototyping techniques permit to obtain accurate control over scaffolding architecture with high reproducibility. Flexible composites are considered to promote mechano-biological stimulation during cell culture. The aim of this study is to fabricate flexible bioceramic scaffolds by robocasting and to determine biological improvements related to their added flexible properties. Characterized 3D ? - TCP/gelatin scaffolds with interconnected porous structure were fabricated using robocasting. SEM micrographs showed fabricated porous scaffolds with desired pore size (~200 ?m), rods diameter (~840 ?m), porosity and mechanical strength. Alamar Blue assay was performed for static and dynamic cultures along 21 days. Oscillatory flow conditions allowed considerable higher cell proliferation compared with static conditions.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925256426&doi=10.1007%2f978-3-319-13117-7_44&partnerID=40&md5=67cd1475e1b87c8df6deea03624c1b61
http://dspace.ucuenca.edu.ec/handle/123456789/22008
ISBN: 9783319131160
ISSN: 16800737
Appears in Collections:Artículos

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