Probióticos en la prevención de enterocolitis necronizante en neonatos pretérminos del servicio de neonatología del Hospital Vicente Corral Moscoso. Cuenca, 2012

Abstract

OBJECTIVE: To compare the frequency of NEC in preterm infants who are receiving probiotics plus conventional therapy in 2012 with patients who received conventional therapy in the neonatal unit of the Vicente Corral Moscoso Hospital in 2011. METHODOLOGY: A cohort study with two groups of 113 premature children in each one. The intervention group received 1g of VSL#3 probiotic in 2012 once daily until discharge, with a maximum of 14 days. During the administration, some cases of NEC were recorded according to the criteria of Bell, and they were compared with the frequency of 113 preterm ECN presented in 2011. RESULTS: In 2011 22.1% of NEC was observed while children who received probiotics showed 10.6%. The groups who represented a statistically significant reduction were the preterm with low weight and moderate preterm (p < 0.05). A smaller percentage (7.5%) of NEC was observed in male infants in relation to females (13.3%) with the administration of VSL # 3. The percentage of NEC was 20% and 25% in male and female respectively who received probiotics. CONCLUSIONS: The VSL # 3 probiotic reduced the frequency of NEC in the preterm neonatal service from the Vicente Corral Moscoso Hospital during 2012, with a relative risk reduction (RRR) of 52%.