Cuji Galarza, Wendy DayannaCabrera Jara, Paúl SebastiánAbril Ortiz, Pedro JoséMachado Orellana, María GabrielaOrellana Paucar, Adriana Monserrath2023-05-172023-05-1720232791-3163https://hinsjou.org/revista/volumen/2023/3/3Introduction In recent years there has been a great interest in investigating the intestinal microbiota and its role both in healthy people and in various pathologies. This has given rise to the concept of the gut-brain axis, where the relationship between the microbiota and neurological pathologies, such as amyotrophic lateral sclerosis, whose pathogenesis is still unclear, is studied Development This review provides an overview of the role of the gut microbiota in the pathogenesis and progression of amyotrophic lateral sclerosis. Conclusions There is evidence of the role of the modulation exerted by the microbiota on the immune state as well as its direct effects on the CNS.es-ESAmyotrophic lateral sclerosisMicrobiotaNeurodegenerative diseasesARTÍCULO