Araujo, Giuliana S.Moulatlet, Gabriel M.Perez Gonzalez, Bolivar AndresCipriani Avila, Eva IsabelTripaldi, PiercosimoCapparelli, Mariana V.Pinos Vélez, Verónica Patricia2023-01-112023-01-1120220007-4861, e 1432-0800https://www.scopus.com/inward/record.uri?eid=2-s2.0-85144129387&doi=10.1007%2fs00128-022-03663-8&partnerID=40&md5=855c756d7bff1b98d9431136e9203c25The effects of emerging contaminants on environmental health are of high concern, especially those potentially induced by mixtures. We assessed single and composite mixtures of triclosan (T), 17β-estradiol (E2), sulfamethoxazole (SMX), and nicotine (N) at various concentrations, on neonates of Daphnia magna. When used in single exposure, T and N induced high toxicity (100% immobility, each one), compared to SMX and E2 (2.5% and 10% immobility, respectively). When T, E2, SMX and N were in mixture, T had the highest contribution to the overall toxicity in mixture exposures. The N toxicity lowered when in a fourfold exposure (85% immobility in fourfold exposure). Due to the high toxicity of T and N, both alone and in the mixtures, our results can serve as a warning about the use of these substances and their release in the aquatic ecosystem. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.es-ESEstradiolAntagonistic effectsNicotineSulfamethoxazoleSynergic effectsTriclosanARTÍCULO10.1007/s00128-022-03663-8