Czarnowski, DanielGerard J., MadlambayanTyler, ParsonsBigoni Ordóñez, Gabriele DavideLuis G., Villa Diaz2021-05-252021-05-2520191574-888X, e2212-3946http://dspace.ucuenca.edu.ec/handle/123456789/36239https://pubmed.ncbi.nlm.nih.gov/30280675/Cancer is a highly prevalent and potentially terminal disease that affects millions of indi- viduals worldwide. Here, we review the literature exploring the intricacies of stem cells bearing tumori- genic characteristics and collect evidence demonstrating the importance of integrin 6 (ITGA6, also known as CD49f) in cancer stem cell (CSC) activity. ITGA6 is commonly used to identify CSC popula- tions in various tissues and plays an important role sustaining the self-renewal of CSCs by interconnect- ing them with the tumorigenic microenvironment.es-ESLamininsIntegrin 6Tumor microenvironmentCancer stem cellsCell signallingSelf-renewalARTÍCULO10.2174/1574888X13666181002151330