Parkhouse , Robert Michael EvansCarpio Rodas, Luis ArturoCortéz, María MilagrosVon Kriegsheim, AlexFesel, Constantin2020-10-262020-10-2620200165-5728https://www.scopus.com/record/display.uri?eid=2-s2.0-85083212219&origin=resultslist&sort=cp-f&src=s&st1=Anti-brain+protein+autoantibodies+are+detectable+in+extraparenchymal+but+not+parenchymal+neurocysticercosis&sid=b2fbc5e0ee15b8875cc87e9759b89bf6&sot=b&sdt=b&sl=122&s=TITLE-ABS-KEY%28Anti-brain+protein+autoantibodies+are+detectable+in+extraparenchymal+but+not+parenchymal+neurocysticercosis%29&relpos=0&citeCnt=2&searchTerm=Neurocysticercosis (NC) presents a spectrum of clinical manifestations, with two broad clinical entities based on the central nervous system location of the parasite: extraparenchymal (EP-NC) and parenchymal (P-NC). In this work, using quantitative immunoblot methodology, we demonstrate the presence of autoantibodies to brain proteins in CSF from EP-NC, but not P-NC, patients. There was striking correlation between the level of autoantibodies and the levels of the secreted metacestode glycoprotein HP-10, suggesting that the level of stimulation of the autoantibody response may be a function of the number of viable parasites. Nine corresponding proteins autoantigens were provisionally identified by mass spectroscopy. © 2020 Elsevier B.V.Neurocysticercosis (NC) presents a spectrum of clinical manifestations, with two broad clinical entities based on the central nervous system location of the parasite: extraparenchymal (EP-NC) and parenchymal (P-NC). In this work, using quantitative immunoblot methodology, we demonstrate the presence of autoantibodies to brain proteins in CSF from EP-NC, but not P-NC, patients. There was striking correlation between the level of autoantibodies and the levels of the secreted metacestode glycoprotein HP-10, suggesting that the level of stimulation of the autoantibody response may be a function of the number of viable parasites. Nine corresponding proteins autoantigens were provisionally identified by mass spectroscopy. © 2020 Elsevier B.V.es-ESAnti-brain autoantibodiesAutoantigensExtraparenchymalHP-10NeurocysticercosisParenchymalARTÍCULO10.1016/j.jneuroim.2020.577234