Pesántez Alvarado, Juan MartínRomero Rodríguez, Valeria PaulinaLafebre Carrasco, Milton FabricioVazquez Ramos, Víctor RafaelReinoso Carrasco, Julieta2019-02-012019-02-0120182373-4345 (e)http://dspace.ucuenca.edu.ec/handle/123456789/31885https://medcraveonline.com/JDHODT/JDHODT-09-00387.pdfOral Squamous Papilloma is the most common benign tumor that can be found in the oral cavity, the main etiological factor is Human Papilloma Virus (HPV), the route of transmission of this virus is through direct contact, despite being a lesion with benign characteristics, it has been observed in recent years that HPV infection is directly associated with the presence of Squamous Cell Carcinoma in the oral cavity, becoming a factor of importance that must be addressed by the different health services worldwide. We present the case of a 63-year-old male patient who attended the Dental Clinic of the Faculty of Dentistry of the Pontificia Universidad Javeriana Bogotá - Colombia. Through the intraoral examination, a papillary lesion on the soft palate was found. An excisional biopsy was performed and the diagnosis is confirmed by histopathological examination.Oral Squamous Papilloma is the most common benign tumor that can be found in the oral cavity, the main etiological factor is Human Papilloma Virus (HPV), the route of transmission of this virus is through direct contact, despite being a lesion with benign characteristics, it has been observed in recent years that HPV infection is directly associated with the presence of Squamous Cell Carcinoma in the oral cavity, becoming a factor of importance that must be addressed by the different health services worldwide. We present the case of a 63-year-old male patient who attended the Dental Clinic of the Faculty of Dentistry of the Pontificia Universidad Javeriana Bogotá - Colombia. Through the intraoral examination, a papillary lesion on the soft palate was found. An excisional biopsy was performed and the diagnosis is confirmed by histopathological examination.es-ESSquamous PapillomaOral CavityARTÍCULO10.15406/jdhodt.2018.09.00387