Gavidia Pazmiño, Jonathan FranciscoIntriago Morales, Ruth VivianaBravo Guapisaca, Maria IsabelÁlvarez Vásquez, José Luis2021-12-092021-12-0920211349-0079, e 1880-3865http://dspace.ucuenca.edu.ec/handle/123456789/37580https://www.scopus.com/record/display.uri?eid=2-s2.0-85120625392&origin=resultslist&sort=plf-f&src=s&sot=b&sdt=b&s=TITLE-ABS-KEY%28Adipokines+in+dental+pulp%3A+Physiological%2C+pathological%2C+and+potential+therapeutic+roles%29Background: Hundreds of adipokines have been identified, and their extensive range of endocrine functions- regulating distant organs such as oral tissues- and local autocrine/paracrine roles have been studied. In dentistry, however, adipokines are poorly known proteins in the dental pulp; few of them have been studied despite their large number. This study reviews recent advances in the investigation of dental-pulp adipokines, with an emphasis on their roles in inflammatory processes and their potential therapeutic applications. Highlights: The most recently identified adipokines in dental pulp include leptin, adiponectin, resistin, ghrelin, oncostatin, chemerin, and visfatin. They have numerous physiological and pathological functions in the pulp tissue: they are closely related to pulp inflammatory mechanisms and actively participate in cell differentiation, mineralization, angiogenesis, and immune-system modulation. Conclusion: Adipokines have potential clinical applications in regenerative endodontics and as biomarkers or targets for the pharmacological management of inflammatory and degenerative processes in dental pulp. A promising direction for the development of new therapies may be the use of agonists/antagonists to modulate the expression of the most studied adipokines.es-ESDental pulp diseaseInflammation mediatorsLeptinAdipokinesRegenerative endodonticsARTÍCULO10.1016/j.job.2021.11.002