Rodriguez Coyago, Maria De lourdesCasariego, Zulema Juana2021-01-082021-01-0820202581-9615https://doi.org/10.30574/wjarr.2020.7.3.0334Psychoneuroimmunoendocrinology studies the interaction between the psyche, neural, endocrine and immune function. There are not many works in the literature on the effect of chronic stress on the stomatognathic system. The objective of this article is to present a clinical case with a group of stomatological manifestations. There are, alterations in systemic stress mediators such as cortisol, and local and systemic immunological disorders. Those could be depend on clinical, biochemical and pathological characteristics established in the skin, as antecedents. We propose that the set of its manifestations are the result of an imbalanced psychoneuroimmunoendocrine axis with overactivation of the HPA axis. It could be also favored, by the cyclothymic personality and anxious profile of the patient, determined after a professional psychological study. This work will allow us to consider the “Psychoneuroimmunology” in the etiopathogenesis of disorders such as temporomandibular joint dysfunction, geographic tongue, and cheilitis.Psychoneuroimmunoendocrinology studies the interaction between the psyche, neural, endocrine and immune function. There are not many works in the literature on the effect of chronic stress on the stomatognathic system. The objective of this article is to present a clinical case with a group of stomatological manifestations. There are, alterations in systemic stress mediators such as cortisol, and local and systemic immunological disorders. Those could be depend on clinical, biochemical and pathological characteristics established in the skin, as antecedents. We propose that the set of its manifestations are the result of an imbalanced psychoneuroimmunoendocrine axis with overactivation of the HPA axis. It could be also favored, by the cyclothymic personality and anxious profile of the patient, determined after a professional psychological study. This work will allow us to consider the “Psychoneuroimmunology” in the etiopathogenesis of disorders such as temporomandibular joint dysfunction, geographic tongue, and cheilitis.es-ESPsychoneuroimmunologyStomatognathic systemBenign migratory glossitisCheilitisTemporomandibular jointCase report