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Title: Maternal supplementation with polyphenols and omega-3 fatty acids during pregnancy: effects on growth, metabolism, and body composition of the offspring
Authors: Heras Molina, Ana
Pesantez Pacheco, Jose Luis
Astiz, Susana
García Contreras, Consolación
Vázquez Gómez, Marta
Encinas, Teresa
Óvilo, Cristina
Isabel, Beatriz
González Bulnes, Antonio
metadata.dc.ucuenca.correspondencia: González Bulnes, Antonio, bulnes@inia.es
Keywords: Antioxidants
Fatty-acids
Intrauterine-growth-restriction
Pregnancy
Swine-model
metadata.dc.ucuenca.areaconocimientofrascatiamplio: 4. Ciencias Agrícolas
metadata.dc.ucuenca.areaconocimientofrascatidetallado: 4.3.1 Ciencias veterinarias
metadata.dc.ucuenca.areaconocimientofrascatiespecifico: 4.3 Medicina Veterinaria
metadata.dc.ucuenca.areaconocimientounescoamplio: 08 - Agricultura, Silvicultura, Pesca y Veterinaria
metadata.dc.ucuenca.areaconocimientounescodetallado: 0841 - Veterinaria
metadata.dc.ucuenca.areaconocimientounescoespecifico: 084 - Veterinaria
Issue Date: 2020
metadata.dc.ucuenca.volumen: Volumen 10, número 11
metadata.dc.source: Animals
metadata.dc.identifier.doi: 10.3390/ani10111946
metadata.dc.type: ARTÍCULO
Abstract: 
Maternal supplementation with antioxidants and n3 PUFAs may be a promising strategy to reduce the risk of intrauterine growth restriction and preterm delivery, which may diminish the appearance of low-birth-weight neonates. The present study aimed to determine benefits and risks of a dietary supplementation combining hydroxytyrosol, a polyphenol from olive leaves and fruits, and n3 PUFAs, from linseed oil, on developmental patterns and metabolic traits of offspring in swine, a model of IUGR pregnancies. The results obtained indicate that maternal supplementation with hydroxytyrosol and n-3 fatty acids during pregnancy has no deleterious effects on the reproductive traits of the sows (prolificacy, homogeneity of the litter, and percentage of stillborns and low-birth-weight, LBW, piglets) and the postnatal features of the piglets (growth patterns, adiposity, and metabolic traits). Conversely, in spite of a lower mean weight and corpulence at birth, piglets from the supplemented sows showed higher average daily weight gain and fractional growth rate. Thus, at juvenile stages afterwards, the offspring from the treated group reached higher weight and corpulence, with increased muscle development and better lipidemic and fatty acid profiles, in spite of similar adiposity, than offspring in the control group. However, much caution and more research are still needed before practical recommendation and use in human pregnancies.
URI: https://www.scopus.com/record/display.uri?eid=2-s2.0-85094592314&doi=10.3390%2fani10111946&origin=inward&txGid=0dd5428ffd9478181afa0ab1374458fa
metadata.dc.ucuenca.urifuente: https://www.mdpi.com/journal/animals
ISSN: 2076-2615
Appears in Collections:Artículos

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