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Please use this identifier to cite or link to this item: http://dspace.ucuenca.edu.ec/handle/123456789/35398
Title: Metformin alleviates obesity and systemic oxidative stress in obese young swine
Authors: Astiz, Isabel
Astiz, Susana
Heras Molina, Ana
Vázquez Gómez, Marta
García Contreras, Consolacion
Pesantez Pacheco, Jose Luis
Gonzalez Bulnes, Antonio
Barbero Fernández, Alicia
metadata.dc.ucuenca.correspondencia: Astiz, Susana, astiz.susana@inia.es
Keywords: Metformin
Obesity
Pediatrics
Oxidative-stress
metadata.dc.ucuenca.areaconocimientofrascatiamplio: 4. Ciencias Agrícolas
metadata.dc.ucuenca.areaconocimientofrascatidetallado: 4.3.1 Ciencias veterinarias
metadata.dc.ucuenca.areaconocimientofrascatiespecifico: 4.3 Medicina Veterinaria
metadata.dc.ucuenca.areaconocimientounescoamplio: 08 - Agricultura, Silvicultura, Pesca y Veterinaria
metadata.dc.ucuenca.areaconocimientounescodetallado: 0841 - Veterinaria
metadata.dc.ucuenca.areaconocimientounescoespecifico: 084 - Veterinaria
Issue Date: 2020
metadata.dc.ucuenca.volumen: Volumen 13, número 7
metadata.dc.source: Pharmaceuticals
metadata.dc.identifier.doi: 10.3390/ph13070142
metadata.dc.type: ARTÍCULO
Abstract: 
The present study assessed the relationship between obesity induced by lifestyle and systemic oxidative stress and possible modulations by oral metformin treatments in young individuals, by using a translational swine model of obesity and associated cardiometabolic disorders (Iberian pig). The results indicate the existence of an age-related increase in both adiposity and systemic oxidative stress (using hydrogen peroxide as a marker), which is higher in individuals with obesogenic lifestyle and increased weight and obesity. Such effect was not found in individuals treated with metformin. The translation of these results suggests that childhood obesity increases production of reactive oxygen species (ROS), and therefore systemic oxidative stress. Treatment with metformin would improve such oxidative status.
URI: http://dspace.ucuenca.edu.ec/handle/123456789/35398
https://www.mdpi.com/1424-8247/13/7/142
metadata.dc.ucuenca.urifuente: https://www.mdpi.com/1424-8247/13/7
ISSN: 1424-8247
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