Logo Repositorio Institucional

Please use this identifier to cite or link to this item: http://dspace.ucuenca.edu.ec/handle/123456789/35359
Title: Extraparenchymal human neurocysticercosis induces autoantibodies against brain tubulin and MOG35–55 in cerebral spinal fluid
Authors: Cortez, Maria
Parkhouse, Michael
Fleury, Agnes
Sciutto, Edda
Carpio Rodas, Luis Arturo
Hernández, Marisela
metadata.dc.ucuenca.correspondencia: Parkhouse, Michael, parkhous@igc.gulbenkian.pt
Keywords: Tubulin
Neurocysticercosis
Anti-brain autoantibodies
Parenchymal
Extraparenchymal
MOGHP10
metadata.dc.ucuenca.areaconocimientofrascatiamplio: 3. Ciencias Médicas y de la Salud
metadata.dc.ucuenca.areaconocimientofrascatidetallado: 3.3.9 Enfermedades Infecciosas
metadata.dc.ucuenca.areaconocimientofrascatiespecifico: 3.3 Ciencias de la Salud
metadata.dc.ucuenca.areaconocimientounescoamplio: 09 - Salud y Bienestar
metadata.dc.ucuenca.areaconocimientounescodetallado: 0912 - Medicina
metadata.dc.ucuenca.areaconocimientounescoespecifico: 091 - Salud
Issue Date: 2020
metadata.dc.ucuenca.volumen: Vol. 349
metadata.dc.source: Journal of Neuroimmunology
metadata.dc.identifier.doi: 10.1016/j.jneuroim.2020.577389
metadata.dc.type: ARTÍCULO
Abstract: 
Neurocysticercosis (NC) presents two broad clinical entities: extraparenchymal (EP-NC) and parenchymal (P-NC). Using ELISA methodology, we demonstrate autoantibodies to tubulin and the Major oligodendrocyte glycoprotein (MOG) in the CSF of most, but not all, EP-NC samples. Levels of these autoantibodies were considerably reduced or absent in the P-NC samples. There was a striking correlation between levels of anti-tubulin and anti-MOG, and the significant correlation between the levels of autoantibodies and cellularity in the CSF, suggests that stimulation of the autoantibody response may be a function of cerebral inflammation. A hypothetical model to describe the pathogenesis of EP-NC is presented
URI: http://dspace.ucuenca.edu.ec/handle/123456789/35359
https://www.scopus.com/record/display.uri?eid=2-s2.0-85091217062&doi=10.1016%2fj.jneuroim.2020.577389&origin=inward&txGid=831beafae4a0d5a058f83bc579e79f18
metadata.dc.ucuenca.urifuente: https://www.sciencedirect.com/journal/journal-of-neuroimmunology
ISSN: 01655728
Appears in Collections:Artículos

Files in This Item:
File Description SizeFormat 
documento.pdfdocument256.62 kBAdobe PDFThumbnail
View/Open


This item is protected by original copyright



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Centro de Documentacion Regional "Juan Bautista Vázquez"

Biblioteca Campus Central Biblioteca Campus Salud Biblioteca Campus Yanuncay
Av. 12 de Abril y Calle Agustín Cueva, Telf: 4051000 Ext. 1311, 1312, 1313, 1314. Horario de atención: Lunes-Viernes: 07H00-21H00. Sábados: 08H00-12H00 Av. El Paraíso 3-52, detrás del Hospital Regional "Vicente Corral Moscoso", Telf: 4051000 Ext. 3144. Horario de atención: Lunes-Viernes: 07H00-19H00 Av. 12 de Octubre y Diego de Tapia, antiguo Colegio Orientalista, Telf: 4051000 Ext. 3535 2810706 Ext. 116. Horario de atención: Lunes-Viernes: 07H30-19H00