Browsing by Author "Palta Gonzalez, Araceli Miroslava"

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Inestabilidad de los microsatélites en cáncer colo-rectal y su distribución de acuerdo a factores pronósticos en SOLCA Cuenca 2004-2014
(Universidad de Cuenca, 2018-06) Murillo Bacilio, Magdali del Rocío; Palta Gonzalez, Araceli Miroslava; Correa Martínez, Fabián Gerardo
Worldwide, colorectal cancer is the third most common neoplasm in men and the second in women. Tumorigenesis pathways allow us to subclassify patients and protocolize treatments. The microsatellite instability constitutes one of these pathways; it is present in a 15% to 20% in colorectal carcinoma; its presence is associated with a better prognosis. Objective: To determine the frequency of microsatellite instability and its distribution according to prognostic factors in biopsies of patients with colorectal cancer in the Solca-Cuenca Cancer Institute during the period 2004-2014. Method: It is an observational, analytical study. About 240 patients with colorectal cancer were studied, they were diagnosed in the Pathology Department of the Cuenca Cancer Institute and who had their biopsy material where the immunohistochemical techniques were performed with 4 markers MLH1, MSH2, MSH6, and PMS2. Results: The 37.9% corresponded to men and 62.1% to women. The average age was 66.2 years. The 58.75% (n = 141) had localization in the colon. A lack of protein expression was observed in 24.2% (58 patients). Regarding to proteins, 68.96% (40 cases) were MLH1 / PMS2; 1.72% (1 case) MSH2 / MSH6. About the cases that did not express the proteins, 87.93% were located in the colon; 79.3% were adenocarcinoma; 58.6% were moderate grade and 37.9% were stage II. In the bivariate analysis, a statistically significant association was established between microsatellite instability with tumor location (OR 7.4, CI 3.2-17) and degree of differentiation (OR 2.8, CI 1.5-5 .4). Conclusions: The protocolized use is recommended within the treatment of colorectal cancer.
Predictive equation of metastasis in patients with malignant ovarian epithelial tumors with the Ca-125 marker
(2018) Sanchez Vega, Juan Fernando; Murillo Bacilio, Magdali Del rocio; Vintimilla Condoy, Adrian Santiago; Palta Gonzalez, Araceli Miroslava; Crespo Astudillo, Jose Alfredo; Mora Bravo, Franklin Geovany
Background: Cancer antigen (CA) 125 (CA-125) is used in ovarian cancer detection and monitoring, whose serum level has a positive correlation with tumor stage. The aim of this study was to obtain a prediction metastasis equation in a group of patients with ovarian cancer based on Ca-125. Methods: A 2-group comparative observational study was conducted at a single oncologic institution (SOLCA) in Cuenca-Ecuador. All patients who were diagnosed with ovarian cancer between January 1996 and December 2016 were included in the current study. Group 1 (G1) patients with the I and II International Federation of Gynecology and Obstetrics (FIGO) stage and Metastasis Group (MG), with III and IV stage, were subdivided. A logistic regression equation was performed to predict metastasis based on Logarithm of serum Ca-125 levels. Results: We included 85 cases in G1 and 64 patients in MG, with 47.8 plusmn; 15 years (G1) and 57.5 ± 13.6 years (MG) of age (P < 0.001). Mortality in G1 was 2 cases (3.1%) and 53 cases (62.4%) in MG (P < 0.001). The CA-125 serum level was 163.5 ± 236 in G1 and 1220.9 ± 1940 u / ml in MG (P < 0.001). The equation to predict metastasis = (Age*0.053) + [(Logarithm Ca-125 value) * 1.078] -8.163 with an OR 2.940 (CI 95% 2.046-4.223) P < 0.001. The sensitivity of the equation was 82.4% and the specificity was 79.7%. Conclusions: It is possible to predict the presence of metastasis in a group of patients with ovarian cancer based on Ca-125. © 2018 The Author(s).