Browsing by Author "Ochoa Cuenca, Gina Paola"

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Virus del papiloma humano y su relación con biomarcadores CDH1 (ECadherina) y SNAI1, El Valle-Cuenca, 2023
(Universidad de Cuenca, 2024-03-08) Lima León, Diana Elizabeth; Ochoa Cuenca, Gina Paola; Bigoni Ordóñez, Gabriele Davide
Cervical cancer, ranked by WHO as the second leading cause of death in women of reproductive age, is attributed to predisposing factors such as early onset of sexual activity and multiple sexual partners. In 2018, WHO recorded more than 70,000 cases of cervical uterine cancer due to HPV worldwide, with 34,000 deaths in the Americas. In a study conducted in Cuenca, Ecuador 2023, 8,723 samples were analyzed, of which 1,349 were positive for serotype 16 (16.68%), serotype 18 (5.51%) and other serotypes (77.81%). The study, of a cross- sectional analytical nature, aimed to determine the presence of Human Papillomavirus and its relationship with the biomarkers E-Cadherin and SNAI1. The results were obtained through a questionnaire, interpreted with tables and percentage values, and analyzed with IBM SPSS and Microsoft Excel programs. The results obtained detail that there is greater predisposition to HPV in single women, with an active sexual life from 16 to 20 years of age, parents of 3 to 4 children, with 1 to 4 sexual partners. Results were also obtained for women affected with high and low risk serotypes together where a decrease in the expression of the biomarker E-Cadherin with expression of SNAI1 is seen, being considered as a progressive epithelial transformation of malignant neoplasms, giving relevance to women over 30 years of age. This study highlights the importance of detecting.