Browsing by Author "Murillo Bacilio, Magdali del Rocío"

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Cáncer de pulmón, características clínico-patológicas en pacientes que acudieron a SOLCA Cuenca (1995-2017)
(2019-05-08) Maldonado Astudillo, Emilio Sebastian; Ochoa Segarra, Juan Jose; Murillo Bacilio, Magdali del Rocío; García Alvear, Jorge Luis
Lung cancer (PC) is the leading cause of cancer death worldwide. The main risk factor is exposure to tobacco smoke, although we can also influence other factors such as: environmental, diet, genetic load. The symptomatology is usually evident. Objective: To describe the clinical pathological characteristics of the patients who assisted to the cancer institute SOLCA Cuenca, with the diagnosis of lung cancer from 1995 to 2017. Methodology: Observational study, descriptive cross-sectional to the clinical histories of the patients who went to the cancer institute SOLCA Cuenca from 1995 to 2017 with diagnosis of lung cancer. This study used descriptive statistics, simple and multiple frequency tables. For its statistical analysis, SPSS version 25 of 2018. Expected results: The diagnosis determined a higher percentage of lung cancer in 2014 with 9.5%; the minimum age of lung cancer presence is 21 years and maximum age 88 years. According to those results, the average is 63.4 years and median 66 years. The highest percentage of lung cancer occurs in males with 57.8%. An average of 62.9% of patients with lung cancer presents smoking habit.
Características clínico-patológicas del cáncer de próstata, Instituto del Cáncer SOLCA, Cuenca, período enero 2012- junio 2017.
(Universidad de Cuenca, 2020-04-28) Aroca Carpio, Christian Sebastián; Espinoza Miranda, María Emilia; Murillo Bacilio, Magdali del Rocío
Background: nowadays prostate cancer is considered a public health issue. According to the last WHO report in 2012, prostate cancer is the fourth most frequent type of cancer, being the fifth cause of death among the male population worldwide. In Ecuador, it is the first cause of death by cancer in men, with a rate of 49 per 100.000 inhabitants. General objective: determine the clinicopathological characteristics of the prostate cancer. Methodology and materials: the descriptive study encompasses the medical histories of the prostate cancer diagnosed patients who were treated in the Cancer Institute (SOLCA) in Cuenca from January 2012 to June 2017. First, a systematic review of the prostate cancer patients’ medical histories was held. Second, the resulting information, collected through a questionnaire made by the authors, was analyzed with the software SPSS 22.0 and Microsoft Excel 2016. Results: in all 335 studied cases, the average age of prostate cancer is 71 years old. The most common histological type was the acinar with 99.4%. The 54.64% of patients presented a stage IIC. The bilateral affection is present in 72.8%. In the Gleason categorization the 73.73% was moderately differentiate. The patient’s body mass rate was pre-obesity with 45.97% of the men. Conclusions: The prostatic cancer is the second most frequent among men, in the majority of cases it is diagnosed in an early stage, where the tumor is inside the prostatic gland, allowing a proper treatment and a favorable prognosis.
Características clínico-patológicas en pacientes con diagnóstico de cáncer gástrico en el Instituto del Cáncer SOLCA Cuenca, en el periodo 2014 – 2019
(Universidad de Cuenca, 2021-07-12) Escandón Patiño, Cristian Eduardo; González González, Kevin Israel; Murillo Bacilio, Magdali del Rocío
Background: The World Health Organization (WHO) states gastric cancer as the first cancer among the cancers with most mortality worldwide. In Ecuador, the National Institute of Statistics and Censuses (INEC) states that this cancer was responsible for 1687 deaths in 2018, representing 2,4% of the total deaths of that year. Objective: To determine the clinical-pathological characteristics in patients with the diagnosis of gastric cancer in the Institute of Cancer SOLCA of Cuenca, from 2014-2019. Method and Materials: a descriptive and retrospective study. The universe was conformed of 719 patients, of whom 549 met the inclusion criteria. The information was recollected from the Institute of Cancer SOLCA Cuenca´s database and was analyzed through SPSS Statistics 25 (free version) and Microsoft Excel 2010. Results: The prevalence of gastric cancer was approximately 1 for every 1000 patients. Regarding sociodemographic variables, the sex was man (52,3%), the age range was 70 – 79-year-olds (25,1%), the marital status was married (61,2%), the living area was urban (64,8%), the instruction was basic (39,2%) and the occupation was unemployed (47,2%). Regarding histopathological variables, the most frequent location was the pylorus (45,4%), the histological type was the tubular adenocarcinoma (62,3%), the differentiation grade was poorly differentiated (G3) in 55,4% and the clinical stage was IV B in 45,4%. Conclusions: Gastric cancer continues being very prevalent in our society, in men of advanced age, and they present with advanced clinical stages at the moment of diagnosis.
Correlación entre estudio citológico y estudio histopatológico en el diagnóstico de Neoplasia Tiroidea. SOLCA - Cuenca. 2009- 2013
(2016) Astudillo Alvarez, Gloria Monserrath; Chacón Andrade, Juan Sebastián; Murillo Bacilio, Magdali del Rocío; Charry Ramírez, José Ricardo
Background. Thyroid neoplasm increasing, drives the search for diagnostic methods with sensitivity and reliable specificity for early advice and treatment to enable longer survival and better quality of life for patients. Cytology method FNA gives a real approximation of malignancy or benign thyroid neoplasia, you can specify the type of cancer, but does not replace histopathological study that defines carcinoma type. Objective: correlating cytology according to the Bethesda system, FNA method histopathology for diagnosis of thyroid neoplasia. Methodology: in retrospective observational design time information from medical records on thyroid punctures from 2009-2013 in SOLCA, Cuenca, Ecuador was collected. Results: the sample comprised 415 patients with thyroid neoplasm were characterized by 89.2% women and an average age of 51.8 ± 15.2 years. 47.2% of patients come from Cuenca and 37.8% of neighboring provinces. 96.4% (188 of 195) of Bethesda cytologic diagnosis category 6 (malignancy) were confirmed by histology. There was correlation (r = 0.49) and significantly moderate agreement (kappa = 0.337) between cytology and histology. The sensitivity was 63% (95% CI 58-69), specificity of 94% (95% CI 89-98), likelihood ratio + 10.9 (95% CI 5-22) and the likelihood ratio - 0.39 (95% 0.3 to 0.4). Conclusion: puncture fine needle aspiration is a valuable diagnostic tool. A puncture made by skilled hands is fast, economical, well tolerated technique, is performed as outpatients and produces samples with reliable results. Bethesda categorization represents a reliable and valid thyroid cytology reporting system
Correlación entre la biopsia por punción por aspiración con aguja fina y el diagnóstico histopatológico definitivo en nódulos mamarios, en el Instituto de Cáncer SOLCA Cuenca 2015-2017
(2018) León Tamayo, Sofía Soledad; Coronel Alvarado, Andrés Gonzalo; Murillo Bacilio, Magdali del Rocío; García Alvear, Jorge Luis
Background: Diagnosis of breast tumor is a challenge not only for general doctors but also for specialists. The fine needle aspiration cytology (FNAC) is an easy to perform procedure that consists of cell aspiration to use in a cytological study. FNAC sensibility is 80% to 97% with a specificity of 78% to 98% (1). Objective: To evaluate the correlation between fine needle aspiration cytology (FNAC) and definitive histopathological diagnostic in breast nodules performed at Instituto de Cáncer SOLCA- Cuenca between 2015 and 2017. Method and Materials: A descriptive study. The study universe was comprised for 229 clinical records from patients to whom a histopathological diagnostic was performed following a FNAC procedure. Statistical analyses will be done using SPSS v19.0 for Windows. Results: A total of 229 clinical records with breast nodules. The patients’ average age was 49.53 years. The breast nodules are predominant in external upper quadrant (53.3%) being present more frequently (58.5%) in the breast left side. According to histopathological study, the 54.1% correspond to non-proliferative lesions followed by a malign condition in a 30.1%, obtaining a sensibility and specificity of the fine needle aspiration cytology (FNAC) of 46.88% and 95.15% respectively. Conclusions: Analyzed indicators allowed to establish that FNAC test can be used as a rapid and low-cost diagnostic method, after which it is necessary to accompany the results of the histological examination
Expresión tisular de proteínas reparadoras del sistema microsatelital y su distribucion de acuerdo a factores pronósticos en cáncer colorrectal en SOLCA-Cuenca 2004-2014
(2017) Murillo Bacilio, Magdali del Rocío; Ugalde Puyol, Jorge Edmundo; Martínez Reyes, Fray Cleiton
Globally, colorectal cancer is the third most common neoplasm in men and the second in women. Its occurrence is related to factors dependent on the patient and molecular alterations. The identification of the pathways of tumorogenesis, allows us to subclassify patients and protocolize treatments. Microsatellite instability is one such path; Is present in 15% to 20% in colorectal carcinoma and its presence is associated with a better prognosis. Objective: To determine the frequency of tissue expression of reparative proteins of the microsatellite system and their distribution according to prognostic factors in biopsies of patients with colorectal cancer attended at the Solca-Cuenca Cancer Institute during the period 2004-2014. Method: It is a cross-sectional, analytical study. Results: We studied 240 patients with colorectal cancer. 37.9% were men and 62.1% were women. The mean age was 66.2 years. The 58.75% (n = 141) had colon location. A lack of protein expression was observed in 24.2% (58 patients). As for proteins, 68.96% (40 cases) were MLH1 / PMS2; 1.72% (1 case) MSH2 / MSH6. Of the cases that did not express the proteins, 87.93% were located in the colon; 79.3% were adenocarcinoma; 58.6% were moderate grade and 37.9% were stage II. In the bivariate analysis, a statistically significant association was established between microsatellite instability with tumor localization (OR 7.4, CI 3.2-17) and degree of differentiation (OR 2.8, CI 1.5-5.4)
Inestabilidad de los microsatélites en cáncer colo-rectal y su distribución de acuerdo a factores pronósticos en SOLCA Cuenca 2004-2014
(Universidad de Cuenca, 2018-06) Murillo Bacilio, Magdali del Rocío; Palta Gonzalez, Araceli Miroslava; Correa Martínez, Fabián Gerardo
Worldwide, colorectal cancer is the third most common neoplasm in men and the second in women. Tumorigenesis pathways allow us to subclassify patients and protocolize treatments. The microsatellite instability constitutes one of these pathways; it is present in a 15% to 20% in colorectal carcinoma; its presence is associated with a better prognosis. Objective: To determine the frequency of microsatellite instability and its distribution according to prognostic factors in biopsies of patients with colorectal cancer in the Solca-Cuenca Cancer Institute during the period 2004-2014. Method: It is an observational, analytical study. About 240 patients with colorectal cancer were studied, they were diagnosed in the Pathology Department of the Cuenca Cancer Institute and who had their biopsy material where the immunohistochemical techniques were performed with 4 markers MLH1, MSH2, MSH6, and PMS2. Results: The 37.9% corresponded to men and 62.1% to women. The average age was 66.2 years. The 58.75% (n = 141) had localization in the colon. A lack of protein expression was observed in 24.2% (58 patients). Regarding to proteins, 68.96% (40 cases) were MLH1 / PMS2; 1.72% (1 case) MSH2 / MSH6. About the cases that did not express the proteins, 87.93% were located in the colon; 79.3% were adenocarcinoma; 58.6% were moderate grade and 37.9% were stage II. In the bivariate analysis, a statistically significant association was established between microsatellite instability with tumor location (OR 7.4, CI 3.2-17) and degree of differentiation (OR 2.8, CI 1.5-5 .4). Conclusions: The protocolized use is recommended within the treatment of colorectal cancer.
Marcador Ca-125, en tumores epiteliales malignos de ovario y factores asociados, en pacientes del Instituto del Cáncer SOLCA, Cuenca 1996 - 2016
(2017) Sánchez Vega, Juan Fernando; Vintimilla Condoy, Adrián Santiago; Murillo Bacilio, Magdali del Rocío; García, Jorge Luis
INTRODUCTION: Ovarian cancer is a leading cause of death in the world, its diagnosis is late, it is a silent killer and a dismal prognosis. Treatment is based on staging. Currently used The Ca-125 for detection, and as a prognostic-follow-up factor. Normal levels are at 35IU/ml; Because of its low sensitivity and specificity, is used with other diagnostic methods such as imaging OBJECTIVE: To determine levels of Ca-125 marker in malignant epithelial ovarian tumors and associated factors in patients from the Cancer Institute SOLCA, Cuenca 1996 - 2016 METHODOLOGY: An observational cross-sectional prevalence study, carried out at SOLCA between 1996 and 2016. Data processed SPSS Statics v15.0. RESULTS: Mean age of 53 years (DS 15.12), 25.50% with a family history of cancer, 75.17% presented parity, of which 4.46% used hormone replacement therapy, the serous epithelial type (81.21%) was the predominant, the most frequent tumor stage was III (32.89%), Ca-125 was positive in 86.58% of the cases. CONCLUSIONS: The prevalence is 1.6 per 1.000 women attended at the consultation, the age of the population was 53 years and a married civil status, concordances were found with other studies regarding the elevation of Ca-125, stages and histological subtypes of cancer
Opinión de los usuarios sobre los servicios de salud en establecimientos públicos con internación
(1993) Juma Fernández, Mónica del Carmen; Matute Ortiz, José Leonidas; Murillo Bacilio, Magdali del Rocío; Naula Sañay, Sara Elizabeth; Ochoa Maldonado, Katty Magaly; Cañizares Aguilar, Aurelio Ernesto
Prevalencia de los tipos moleculares de cáncer de mama y características clínico-patológicas, SOLCA, Cuenca, agosto 2010 – julio 2017
(2018-03-19) Jaigua Rodríguez, Juan Diego; Romo Urgilés, Juan Diego; Murillo Bacilio, Magdali del Rocío; García Alvear, Jorge Luis
Background: Breast cancer, according to the WHO, is the most common cancer in women worldwide, and in Ecuador it has an incidence of 30 cases per 100,000 inhabitants per year. Historically, it was classified according to clinical characteristics, stage and tumor grade. The molecular classification is used in the diagnosis of challenging lesions and to differentiate the subtypes of lesions, with prognostic character. Main Objective: To determine the prevalence of molecular types of breast cancer and its clinical-pathological characteristics in patients of “Instituto del Cáncer SOLCA – Cuenca” in the period August 2010 - July 2017. Method and Materials: Analytical and cross-sectional study. 582 clinical records that met the selection criteria were analyzed. The information obtained from the database of “Instituto del Cáncer SOLCA”, and extrapolated to the collection form. The software SPSS 19.0 was used for its analysis. Results: The most prevalent molecular type is Luminal A (35.22%), its predominant histological type is ductal (92.96%), increasing its prevalence after the age of 40 years old (92,26%). The clinical stage with the highest prevalence is IIA (29.21%) and according to Nottingham score, 76.80% was grade III. Conclusions: The molecular types of breast cancer are statistically associated with the clinical characteristics: age and family pathological background; and the pathological characteristics: histological type, Nottingham score and clinical stage.
Programa educativo para la prevención del cáncer de cuello uterino
(Universidad de Cuenca, 2017) Campoverde Cisneros, Manuel Alfredo; Jiménez Brito, Doriz Angélica; Vega Crespo, Bernardo José; Salazar Torres, Zoila Katherine; Freire Argudo, Marco Vinicio; Ortiz Segarra, José Ignacio; Palacios Espinoza, Elvira del Carmen; Murillo Bacilio, Magdali del Rocío; Viñansaca Atancuri, Lourdes Catalina
Sobre-expresión de la proteína p 16 en biopsias con diagnóstico de NIC I, positivas para Genoma de Papiloma Virus Humano. Instituto del Cáncer. SOLCA Cuenca-Ecuador. 2009-2010.
(Universidad de Cuenca. Facultad de Ciencias Médicas, 2015-12) Murillo Bacilio, Magdali del Rocío; Ugalde Puyol, Jorge Edmundo; Palta González, Araceli Miroslava; Picón Coronel, María Gabriela
Numerous studies report that overexpression of p16 protein that is a biomarker to identify premalignant exocervical epithelium lesions would have a high association with human papillomavirus (HPV) with high oncogenic risk. It is a descriptive correlational study whose objective was to establish association of Cervical Intraepithelial Neoplasia grade I (CIN I), HPV positive, with the p16 expression. Materials, methods and results: It is a correlational study conducted from November 2009 to November 2010; about 256 cases of CIN I were presented, 72 were positive HPV; also p16 technique was performed. The women average age was 41 years. There were 40 (55.6%) positive cases for p16, and only 32 (44.4%) were negative. From the positive cases for p16, the most common viral types were high-risk patients: 33 (82.5%). The p16 was valued in amount, distribution and intensity, establishing a relationship between the intensity of p16 with high-risk virus (p = 0.038). When the age and viral type were analyzed, patients between 20 and 40 years (36 cases, 90%) presented HPV genome with high risk. Conclusions: There is correlation between the intensity of p16 with the presence of HPV high risk, helping select groups prone to disease progression.