Browsing by Author "Gonzalez Ortiz, Diana Patricia"

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Hodgkin and non-hodgkin lymphoma: from a molecular, diagnostic and therapeutic perspective
(2021) González Bracho, Jorge Rafael
Lymphomas are a heterogeneous set of malignancies, which have more than 100 entities that are derived from precur-sor or mature cells of the B, T, and NK lymphocytic lineages. Worldwide, these neoplasms affect between 3 to 6 people per 100,000 inhabitants, representing the fifth most common cancer and the fifth leading cause of cancer death. Traditionally they have been classified into two large groups, Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Moreover, due to technological advances in areas such as immunol-ogy and genetics, different mechanisms have been identified through which lymphocytic neoplastic cells manage to evade antitumor surveillance, alter immunological checkpoints and condition their tumor microenvironment, thus guaranteeing its perpetuation. The initial diagnosis of lymphoma, based on clinical findings and identification of risk factors, must be confirmed by performing a lymph node biopsy. Chemo-radio-therapy is one of the first-line therapeutic strategies, although in recent years different biological therapies such as immu-notherapy have been developed, which have proven to be effective in controlling the disease. Because the pathogenic mechanisms of lymphomagenesis have important implications for diagnosis and clinical treatment, this review synthe-sizes current information on the pathophysiological processes underlying these neoplasms, summarizes the basic no-tions about their diagnostic approach, and presents evidence on the efficacy and safety of currently used first and second line treatments. © 2021, Venezuelan Society of Pharmacology and Clinical and Therapeutic Pharmacology.
Lipid profile and its relationship with body mass index in adolescents of the Particular Educational Unit “Universitaria de Azogues”, Ecuador
(2019) Alvarez Ochoa, Robert Ivan; Conchado Martinez, Julio Hector; Garces Ortega, Juan Pablo; Cordero Cordero, Gabriela Del rosario; Saquicela Espinoza, Luis Alberto; Chuquiralagua Ruiz, Paul Emanuel; Yumisaca Tiuquinga, Silvia Veronica; Gonzalez Ortiz, Diana Patricia; Torres Perez, Angelica Estefania; Rodriguez Torres, Diego Andres
All rights reserved. Introduction: Dyslipidemia and excess weight in adolescents are risk factors for the development of cardiovascular diseases both in this period and in adulthood. Materials and methods: a cross-sectional descriptive study was carried out that included 74 third and fourth year students of the “Private Educational Unit “Universi-tary of Azogues”, to which the body mass index (BMI) was determined from the weight and height, proceeding later to the extraction of a blood sample for the assessment of the lipid profile. Total cholesterol (TC), HDL-cholesterol (c-HDL) and triglycerides (TG) levels were determined using commercial kits (Spinreact®) and LDL-cholesterol (c-LDL) according to Human Frisonex®. Results: It was evidenced in the analysis that 70.3% of students had normal weight and 29.7% were overweight. 35.1% had CT levels in the limit and 9.5% were high. 51.3% showed TG levels and in 9.5% they were high. 94.6% had acceptable levels of c-HDL and c-LDL. 8.1% of the overweight students had high levels of CT and TG. Conclusions: 29.7% of adolescents were overweight and a significantly higher percentage (8.1%) high levels of CT and TG. The percentages of adolescents with overweight, limit and high levels of CT and TG suggest the need to follow them.