Browsing by Author "Bravo Guapisaca, María Isabel"

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    Adipokines in dental pulp: physiological, pathological and potential therapeutic roles
    (Universidad de Cuenca, 2022-02-11) Gavidia Pazmiño, Jonathan Francisco; Bravo Guapisaca, María Isabel; Intriago Morales, Ruth Viviana
    Background: Hundreds of adipokines have been identified, and their extensive range of endocrine functions—regulating distant organs such as oral tissues—and local autocrine/paracrine roles have been studied. In dentistry, however, adipokines are poorly known proteins in the dental pulp; few of them have been studied despite their large number. This study reviews recent advances in the investigation of dental-pulp adipokines, with an emphasis on their roles in inflammatory processes and their potential therapeutic applications. Highlights: The most recently identified adipokines in dental pulp include leptin, adiponectin, resistin, ghrelin, oncostatin, chemerin, and visfatin. They have numerous physiological and pathological functions in the pulp tissue: they are closely related to pulp inflammatory mechanisms and actively participate in cell differentiation, mineralization, angiogenesis, and immune-system modulation. Conclusion: Adipokines have potential clinical applications in regenerative endodontics and as biomarkers or targets for the pharmacological management of inflammatory and degenerative processes in dental pulp. A promising direction for the development of new therapies may be the use of agonists/antagonists to modulate the expression of the most studied adipokines.
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    Análisis comparativo entre las técnicas de medición manual-tradicional y digital de los espacios intercanino e intermolar en modelos de estudio
    (2016) Bravo Guapisaca, María Isabel; Criollo Romero, Mónica Andrea; Cazar Almache, Marcelo Enrique; Bravo Calderón, Manuel Estuardo
    Introduction: The aim of this study was to compare manual - traditional and digital measurement techniques for analysis of intercanine and intermolar spaces. The study models of 27 patients in the Orthodontic Department of the School of Dentistry at the Universidad de Cuenca were used to determine whether or not the two evaluation techniques were coincidental at the time of measurement. Materials and methods: A physical and a digital model of each of the 27 patients meeting the inclusion criteria were used from the files between March 2013 and October 2015. The manual-traditional analysis was performed using a digital caliper Mitutoyo 500-196-30. The digital analysis was done with diagnostic software NemoCast 3D models. The SPSS 19.0 program was used to study the data. The Kolmogorov-Smirnov Test was used to determine normality, consequently the Student T–Test was applied. The researchers involved in the analysis had previous training on standards and work manuals for the appropriate handling of a digital caliper and a digital scanner. Results and conclusions: The results of the measures are: the manual - traditional intercanine measurement space is 0.642 and digital intercanine measurement space is 0.684, while manual - traditional intermolar measurement space is 0.770 and digital intermolar measurement space is 0.640 ; these results obtain a nonsignificant difference of 0.717 intercanine space and 0.130 intermolar space; this verifying the hypothesis that is no difference between measures of intercanine and intermolar spaces obtained from manual - traditional and digital techniques