Validación del volumen plaquetario medio como predictor de severidad de preeclampsia

Abstract

Preeclampsia is a serious complication that can occur during pregnancy, and is associated with considerable maternal and fetal morbidity and mortality. Therefore, laboratory tests that allow its prediction are undoubtedly of great support in obstetric practice. The objective of this study was to determine the validity of the mean platelet volume as a predictor of the severity of preeclampsia in patients treated at the Vicente Corral Moscoso Hospital, in the period 2019. This is a diagnostic test valida- tion study. 387 pregnant women who met the inclusion criteria were included. For the diagnosis of severity of preeclampsia, the protein/creatinine index was applied. To determine the validity of the mean platelet volume in severity, the cut-off point for this population of >11.65 fl was used, obtained using the Youden Index. Descriptive statis- tics and sensitivity, specificity, predictive va- lues, ROC curve and Fagan’s nanogram were applied. Mean platelet volume did not prove to be a test with optimal predictive capacity for the severity of preeclamptic symptoms, since the value of the area under the cur- ve was 0.44 (95% CI = 0.38-0.50), however,the proportion of women confirmed as mild preeclamptic by the negative result of the test (≤ 11.65 fL) was 87.92% (95% CI = 82.35 – 93.49). The pre-test probability corresponds to the prevalence of severe preeclampsia of 61% with a likelihood ratio of 1.89, however, with a positive result of MPV (>11.65), the frequency of presentation of severe preeclampsia increased to 75%.