Please use this identifier to cite or link to this item:
http://dspace.ucuenca.edu.ec/handle/123456789/37916Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Astudillo Ortiz, Esteban Andres | - |
| dc.contributor.author | Gomes, Manuela | - |
| dc.contributor.author | Reis, Rui | - |
| dc.contributor.author | Babo, Pedro | - |
| dc.date.accessioned | 2022-02-01T19:17:20Z | - |
| dc.date.available | 2022-02-01T19:17:20Z | - |
| dc.date.issued | 2021 | - |
| dc.identifier.issn | 1996-1944 | - |
| dc.identifier.uri | http://dspace.ucuenca.edu.ec/handle/123456789/37916 | - |
| dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85120385764&origin=resultslist&sort=plf-f&src=s&st1=Evaluation+of+injectable+hyaluronic+acid-based+hydrogels+for+endodontic+tissue+regeneration&sid=e7b8595ddbab92f7a14f0199da6b766b&sot=b&sdt=b&sl=106&s=TITLE-ABS-KEY%28Evaluation+of+injectable+hyaluronic+acid-based+hydrogels+for+endodontic+tissue+regeneration%29&relpos=0&citeCnt=0&searchTerm=&retries=1 | - |
| dc.description | Dental pulp tissue engineering (TE) endeavors to regenerate dentin/pulp complex by combining a suitable supporting matrix, stem cells, and biochemical stimuli. Such procedures foresee a matrix that can be easily introduced into the root canal system (RCS) and tightly adhere to dentin walls to assure the dentin surface’s proper colonization with progenitor cells capable of restoring the dentin/pulp complex. Herein was investigated an injectable self-setting hyaluronic acid-based (HA) hydrogel system, formed by aldehyde-modified (a-HA) with hydrazide-modified (ADH), enriched with platelet lysate (PL), for endodontic regeneration. The hydrogels’ working (wT) and setting (sT) times, the adhesion to the dentine walls, the hydrogel’s microstructure, and the delivery of human dental pulp cells (DPCs) were studied in vitro. Hydrogels incorporating PL showed a suitable wT and sT and a porous microstructure. The tensile tests showed that the breaking point occurs after 4.3106 ± 1.8677 mm deformation, while in the indentation test after 1.4056 ± 0.3065 mm deformation. Both breaking points occur in the hydrogel extension. The HA/PL hydrogels exhibited supportive properties and promoted cell migration toward dentin surfaces in vitro. Overall, these results support using PL-laden HA injectable hydrogels (HA/PL) as a biomaterial for DPCs encapsulation, thereby displaying great clinical potential towards endodontic regenerative therapies. | - |
| dc.language.iso | es_ES | - |
| dc.source | Materials | - |
| dc.subject | Hyaluronic acid | - |
| dc.subject | Endodontic tissue regeneration | - |
| dc.subject | Tissue engineering | - |
| dc.subject | Injectable | - |
| dc.subject | Hydrogels | - |
| dc.title | Evaluation of injectable hyaluronic acid-based hydrogels for endodontic tissue regeneration | - |
| dc.type | ARTÍCULO | - |
| dc.ucuenca.idautor | 0000-0002-2036-6291 | - |
| dc.ucuenca.idautor | 0102851185 | - |
| dc.ucuenca.idautor | 0000-0003-4347-599X | - |
| dc.ucuenca.idautor | 0000-0002-4295-6129 | - |
| dc.identifier.doi | 10.3390/ma14237325 | - |
| dc.ucuenca.version | Versión publicada | - |
| dc.ucuenca.areaconocimientounescoamplio | 09 - Salud y Bienestar | - |
| dc.ucuenca.afiliacion | Babo, P., Universidade do Minho (Braga), Braga, Portugal | - |
| dc.ucuenca.afiliacion | Astudillo, E., Universidade do Minho (Braga), Braga, Portugal; Astudillo, E., Universidad de Cuenca, Facultad de Odontología, Cuenca, Ecuador | - |
| dc.ucuenca.afiliacion | Reis, R., Universidade do Minho (Braga), Braga, Portugal | - |
| dc.ucuenca.afiliacion | Gomes, M., Universidade do Minho (Braga), Braga, Portugal | - |
| dc.ucuenca.volumen | Volumen 14, número 23 | - |
| dc.ucuenca.indicebibliografico | SCOPUS | - |
| dc.ucuenca.factorimpacto | 0.682 | - |
| dc.ucuenca.cuartil | Q2 | - |
| dc.ucuenca.numerocitaciones | 0 | - |
| dc.ucuenca.areaconocimientofrascatiamplio | 3. Ciencias Médicas y de la Salud | - |
| dc.ucuenca.areaconocimientofrascatiespecifico | 3.2 Medicina Clínica | - |
| dc.ucuenca.areaconocimientofrascatidetallado | 3.2.15 Odontología | - |
| dc.ucuenca.areaconocimientounescoespecifico | 091 - Salud | - |
| dc.ucuenca.areaconocimientounescodetallado | 0911 - Estudios Dentales | - |
| dc.ucuenca.urifuente | https://www.mdpi.com/1996-1944/14/23 | - |
| Appears in Collections: | Artículos | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| documento.pdf | document | 2.13 MB | Adobe PDF |  View/Open |
This item is protected by original copyright |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
Centro de Documentacion Regional "Juan Bautista Vázquez" | ||||||||||
| ||||||||||