Anticuerpos antipéptico citruliano en pacientes con artritis reumatoide. Hospital Vicente Corral Moscoso, Facultad de Ciencias Médicas. Cuenca. 2008

Abstract

Objective: To determine the sensibility and specificity of the anti-péptico citruliano antibodies versus rheumatoid factor in the diagnosis of patients with rheumatoid arthritis in the Vicente Corral Moscoso Hospital Methods: Two groups, 30 patients with rheuma - toid arthritis according to American College of Rheumatology criteria and 30 control patients were established. They assisted the Vicente Corral Moscoso Hospital ′s Rheumatologic Department from January to May 2008. The laboratory tests were carried out and the results were confronted. The statistic analysis included specificity, sensibility, negative and positive predictor values. Results: The determination of anti-citrulline anti - bodies ELISA second generation show a 53,3% of sensibility, 83,3% of specificity, positive predictor value of 76,19 % and a negative predictor value of 64,10%; to third generation the sensibility was 50%, specificity 86,67%, positive predictor value of 78.95% and a negative predictor value of 63,41 % and the Rheumatoid Factor IgM sen - sibility 53,3%, specificity 70%, positive predictor value 64% and negative predictor value 60%. Conclusion: anti-citrulline antibodies ELISA have a better specificity than Rheumatoid Factor; the sensibility was the same in both tests.