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DC Field | Value | Language |
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dc.contributor.author | Carpio Rodas, Luis Arturo | |
dc.date.accessioned | 2024-03-04T20:13:21Z | - |
dc.date.available | 2024-03-04T20:13:21Z | - |
dc.date.issued | 2024 | |
dc.identifier.issn | 2470-9239 | |
dc.identifier.uri | http://dspace.ucuenca.edu.ec/handle/123456789/44037 | - |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85185695350&doi=10.1002%2fepi4.12900&origin=inward&txGid=fe1c6819b0bac384f4053ce8cb98b906 | |
dc.description.abstract | There are limited data on first seizure (FS) among adults in low and middle-income countries. We describe findings from a prospective cohort study involving 180 adults presenting with seizures in emergency departments in five Latin American countries. Overall, 102 participants (56.7%) had acute symptomatic seizures (ASyS) while 78 (43.3%) had unprovoked seizures (UPS). Among patients with ASyS, 55 (53.9%) had structural causes, with stroke (n = 24, 23.5%), tumor (n = 10, 9.8%), and trauma (n = 3, 3%) being the most frequent. Nineteen patients (18.6%) had infectious causes, including four (4%) with meningoencephalitis, three (3%) neurocysticercosis, and two (2%) bacterial meningoencephalitis. Twenty patients (19.6%) had metabolic/toxic evidence, including four (4%) with uremic encephalopathy, two (2%) hyponatremia, and three (3%) acute alcohol intoxication. Immune dysfunction was present in seven (7%) patients and neurodegenerative in two (2%). Among participants with UPS, 45 (57.7%) had unknown etiology, 24 (30.7%) had evidence of structural disorders (remote symptomatic), four (5%) were related to infectious etiology (>7 days before the seizure), and five (6.4%) had genetic causes. During the 3- and 6-month follow-up, 29.8% and 14% of patients with UPS, respectively, experienced seizure recurrence, while 23.9% and 24.5% of patients with ASyS had seizure recurrence. Longer follow-up is necessary to assess seizure recurrence for patients with ASyS after the acute cause is resolved and to determine the 10-year risk of recurrence, which is part of the definition of epilepsy. Plain Language Summary: We monitored 180 adults who presented with their first seizure in emergency departments across five Latin American countries. Among these patients, 57% had acute symptomatic seizures, with structural causes such as stroke (23%), infection (17%), or tumor (10%) being more prevalent. Among the 43% with unprovoked seizures, 58% showed no identifiable acute cause, while 6.4% were due to genetics. Within 3 months after their initial seizure, 26.6% of individuals experienced a second seizure, with 11.9% continuing to have seizures in Months 3–6. Between Months 3 and 6, an additional 20% of patients encountered a second seizure. Research is needed to better understand the cause and prognosis of these patients to improve outcomes. | |
dc.language.iso | es_ES | |
dc.source | Epilepsia Open | |
dc.subject | Acute symptomatic seizures | |
dc.subject | First seizure | |
dc.subject | Etiology | |
dc.subject | Epilepsy | |
dc.subject | Neurocysticercosis | |
dc.title | Causes and prognosis of adults experiencing a first seizure in adulthood: A pilot cohort study conducted in five countries in Latin America | |
dc.type | ARTÍCULO | |
dc.ucuenca.idautor | 0100737956 | |
dc.identifier.doi | 10.1002/epi4.12900 | |
dc.ucuenca.version | Versión publicada | |
dc.ucuenca.areaconocimientounescoamplio | 09 - Salud y Bienestar | |
dc.ucuenca.afiliacion | Carpio, L., Universidad de Cuenca, Facultad de Ciencias Médicas, Cuenca, Ecuador; Carpio, L., Hospital Santa Inés, Cuenca, Ecuador | |
dc.ucuenca.correspondencia | Carpio Rodas, Luis Arturo, arturo.carpio@ucuenca.edu.ec | |
dc.ucuenca.volumen | Volumen 0, número 0 | |
dc.ucuenca.indicebibliografico | SCOPUS | |
dc.ucuenca.factorimpacto | 1051 | |
dc.ucuenca.cuartil | Q2 | |
dc.ucuenca.numerocitaciones | 0 | |
dc.ucuenca.areaconocimientofrascatiamplio | 3. Ciencias Médicas y de la Salud | |
dc.ucuenca.areaconocimientofrascatiespecifico | 3.2 Medicina Clínica | |
dc.ucuenca.areaconocimientofrascatidetallado | 3.2.30 Otros Temas de Medicina Clínica | |
dc.ucuenca.areaconocimientounescoespecifico | 091 - Salud | |
dc.ucuenca.areaconocimientounescodetallado | 0912 - Medicina | |
dc.ucuenca.urifuente | https://onlinelibrary.wiley.com/journal/24709239 | |
Appears in Collections: | Artículos |
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documento.pdf | 502.13 kB | Adobe PDF | View/Open |
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