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DC Field | Value | Language |
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dc.contributor.author | Trevisani, Francesco | |
dc.contributor.author | García Contreras, Consolación | |
dc.contributor.author | González Bulnes, Antonio | |
dc.contributor.author | Yeste Vizcaino, Natalia | |
dc.contributor.author | Esteban, Porrini | |
dc.contributor.author | Pesantez Pacheco, Jose Luis | |
dc.contributor.author | Bassols, Anna | |
dc.contributor.author | Vázquez Gómez, Marta | |
dc.contributor.author | Lima, Sergio Luis | |
dc.contributor.author | Bettiga, Arianna | |
dc.contributor.author | Heras Molina, Ana | |
dc.date.accessioned | 2023-01-25T16:10:40Z | - |
dc.date.available | 2023-01-25T16:10:40Z | - |
dc.date.issued | 2022 | |
dc.identifier.issn | 2079-7737 | |
dc.identifier.uri | http://dspace.ucuenca.edu.ec/handle/123456789/40873 | - |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85140403664&doi=10.3390%2fbiology11101533&origin=inward&txGid=7b7028b9c5c773fb64c6d08adbe411ae | |
dc.description.abstract | Intrauterine growth restriction (IUGR) and later obesity and metabolic disorders have classically been associated with maternal malnutrition, but most cases of IUGR are related to placental insufficiency. The current study, using a swine model for IUGR and obesity, aimed to determine the interaction of birth weight (categorized as low birth weight [LBW] or normal birth-weight [NBW]) and postnatal diet (categorized as maintenance diet [MD] or fattening diet [FD]) on body weight, adiposity and metabolic traits. FD induced higher body weight and adiposity (both p < 0.0001), with higher fructosamine levels (p < 0.005) and a trend toward higher HOMA-β index (p = 0.05). NBW pigs remained heavier than LBW pigs during the early juvenile period (p < 0.005), but there were no differences at later stages. There were no differences in metabolic traits during juvenile development, but there were differences in adulthood, when LBW pigs showed higher glucose and lower insulin levels than NBW pigs (both p < 0.05). These results suggest that (a) FD allows LBW offspring to achieve similar obesity in adulthood as NBW offspring, and (b) glucose metabolism is more compromised in obese LBW than obese NBW pigs. The comparison of our data with previous studies highlights significant differences between offspring with LBW induced by maternal malnutrition or placental insufficiency, which should be considered when studying the condition. | |
dc.language.iso | es_ES | |
dc.source | Biology | |
dc.subject | Intrauterine growth restriction | |
dc.subject | Animal models | |
dc.subject | Translational medicine | |
dc.subject | Obesity | |
dc.title | Obesity and metabolic traits after high-fat diet in iberian pigs with low birth weight of placental origin | |
dc.type | ARTÍCULO | |
dc.ucuenca.idautor | 0000-0003-3540-8252 | |
dc.ucuenca.idautor | 0104911193 | |
dc.ucuenca.idautor | 0000-0001-7496-9680 | |
dc.ucuenca.idautor | 0000-0003-4213-2274 | |
dc.ucuenca.idautor | 0000-0003-2471-2064 | |
dc.ucuenca.idautor | 0000-0002-3056-4662 | |
dc.ucuenca.idautor | 0000-0003-4624-2585 | |
dc.ucuenca.idautor | 0000-0002-9718-0903 | |
dc.ucuenca.idautor | 0000-0002-0917-4475 | |
dc.ucuenca.idautor | 0000-0003-4205-8959 | |
dc.ucuenca.idautor | 9044674200 | |
dc.identifier.doi | 10.3390/biology11101533 | |
dc.ucuenca.version | Versión publicada | |
dc.ucuenca.areaconocimientounescoamplio | 09 - Salud y Bienestar | |
dc.ucuenca.afiliacion | Vázquez, M., Departamento de Reproducción Animal (INIA), Madrid, España | |
dc.ucuenca.afiliacion | Heras, A., Departamento de Reproducción Animal (INIA), Madrid, España; Heras, A., Universidad Complutense de Madrid, Madrid, España | |
dc.ucuenca.afiliacion | Yeste, N., Universitat Autónoma de Barcelona UAB, Barcelona, España | |
dc.ucuenca.afiliacion | Pesantez, J., Universidad de Cuenca, Facultad de Ciencias Agropecuarias, Cuenca, Ecuador; Pesantez, J., Departamento de Reproducción Animal (INIA), Madrid, España | |
dc.ucuenca.afiliacion | Bettiga, A., Urological Research Institute (IRCCS), San Raffaele, Italia | |
dc.ucuenca.afiliacion | Trevisani, F., Urological Research Institute (IRCCS), San Raffaele, Italia | |
dc.ucuenca.afiliacion | García, C., Departamento de Reproducción Animal (INIA), Madrid, España; García, C., Estación Experimental del Zaidín (CSIC), Granada, España | |
dc.ucuenca.afiliacion | Lima, S., Fundación Jiménez Díaz (IIS), Madrid, España | |
dc.ucuenca.afiliacion | Bassols, A., Universitat Autónoma de Barcelona UAB, Barcelona, España | |
dc.ucuenca.afiliacion | Esteban, P., Hospital Universitario de Canarias, San Cristóbal de La Laguna, España | |
dc.ucuenca.afiliacion | González, A., Departamento de Reproducción Animal (INIA), Madrid, España; González, A., Universidad Complutense de Madrid, Madrid, España; González, A., Universidad Cardenal Herrera CEU (Valencia), Valencia, España | |
dc.ucuenca.correspondencia | González Bulnes, Antonio, antonio.gonzalezbulnes@uchceu.es | |
dc.ucuenca.volumen | Volumen 11, número 10 | |
dc.ucuenca.indicebibliografico | SCOPUS | |
dc.ucuenca.factorimpacto | 0.903 | |
dc.ucuenca.cuartil | Q1 | |
dc.ucuenca.numerocitaciones | 0 | |
dc.ucuenca.areaconocimientofrascatiamplio | 3. Ciencias Médicas y de la Salud | |
dc.ucuenca.areaconocimientofrascatiespecifico | 3.2 Medicina Clínica | |
dc.ucuenca.areaconocimientofrascatidetallado | 3.2.2 Ginecología y Obstetricia | |
dc.ucuenca.areaconocimientounescoespecifico | 091 - Salud | |
dc.ucuenca.areaconocimientounescodetallado | 0912 - Medicina | |
dc.ucuenca.urifuente | https://www.mdpi.com/2 | |
Appears in Collections: | Artículos |
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documento.pdf | 1.61 MB | Adobe PDF | View/Open |
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