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DC Field | Value | Language |
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dc.contributor.author | González Bulnes, Antonio | |
dc.contributor.author | Yeste Vizcaíno, Natalia | |
dc.contributor.author | Pérez Valle, Jorge | |
dc.contributor.author | Heras Molina, Ana | |
dc.contributor.author | Pesantez Pacheco, Jose Luis | |
dc.contributor.author | Bassols, Ana | |
dc.contributor.author | Porrini, Esteban | |
dc.date.accessioned | 2023-01-09T17:05:47Z | - |
dc.date.available | 2023-01-09T17:05:47Z | - |
dc.date.issued | 2022 | |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | http://dspace.ucuenca.edu.ec/handle/123456789/40637 | - |
dc.identifier.uri | https://www.scopus.com/record/display.uri?eid=2-s2.0-85137457996&origin=resultslist&sort=cp-f&src=s&st1=A+High-Fat+Diet+Modifies+Brain+Neurotransmitter+Profile+and+Hippocampal+Proteome+and+Morphology+in+an+IUGR+Pig+Model&sid=7dfdefc25fb6d784bfe0a58a21758e39&sot=b&sdt=b&sl=131&s=TITLE-ABS-KEY%28A+High-Fat+Diet+Modifies+Brain+Neurotransmitter+Profile+and+Hippocampal+Proteome+and+Morphology+in+an+IUGR+Pig+Model%29&relpos=0&citeCnt=0&searchTerm= | |
dc.description.abstract | Intrauterine Growth Restriction (IUGR) hinders the correct growth of the fetus during pregnancy due to the lack of oxygen or nutrients. The developing fetus gives priority to brain development (“brain sparing”), but the risk exists of neurological and cognitive deficits at short or long term. On the other hand, diets rich in fat exert pernicious effects on brain function. Using a pig model of spontaneous IUGR, we have studied the effect on the adult of a long-term high-fat diet (HFD) on the neurotransmitter profile in several brain areas, and the morphology and the proteome of the hippocampus. Our hypothesis was that animals affected by IUGR (born with low birth weight) would present a different susceptibility to an HFD when they become adults, compared with normal birth-weight animals. Our results indicate that HFD affected the serotoninergic pathway, but it did not provoke relevant changes in the morphology of the hippocampus. Finally, the proteomic analysis revealed that, in some instances, NBW and LBW individuals respond to HFD in different ways. In particular, NBW animals presented changes in oxidative phosphorylation and the extracellular matrix, whereas LBW animals presented differences in RNA splicing, anterograde and retrograde transport and the mTOR pathway. | |
dc.language.iso | es_ES | |
dc.source | Nutrients | |
dc.subject | Pig | |
dc.subject | Brain | |
dc.subject | High-fat diet | |
dc.subject | Hippocampus | |
dc.subject | Intrauterine growth restriction | |
dc.subject | Metabolism | |
dc.subject | Neurotransmitters | |
dc.title | A high-fat diet modifies brain neurotransmitter profile and hippocampal proteome and morphology in an IUGR pig model | |
dc.type | ARTÍCULO | |
dc.ucuenca.idautor | 0000-0001-7496-9680 | |
dc.ucuenca.idautor | 0104911193 | |
dc.ucuenca.idautor | 0000-0003-4213-2274 | |
dc.ucuenca.idautor | 0000-0003-2471-2064 | |
dc.ucuenca.idautor | 0000-0002-0917-4475 | |
dc.ucuenca.idautor | 0000-0002-1100-132X | |
dc.ucuenca.idautor | 0000-0002-3056-4662 | |
dc.identifier.doi | 10.3390/nu14163440 | |
dc.ucuenca.version | Versión publicada | |
dc.ucuenca.areaconocimientounescoamplio | 08 - Agricultura, Silvicultura, Pesca y Veterinaria | |
dc.ucuenca.afiliacion | Pesantez, J., Universidad de Cuenca, Facultad de Ciencias Agropecuarias, Cuenca, Ecuador | |
dc.ucuenca.afiliacion | Heras, A., Universitat Autónoma de Barcelona UAB, Barcelona, España | |
dc.ucuenca.afiliacion | Pérez, J., Universitat de Barcelona, Barcelona, España | |
dc.ucuenca.afiliacion | Yeste, N., Universitat Autónoma de Barcelona UAB, Barcelona, España | |
dc.ucuenca.afiliacion | Porrini, E., Hospital Universitario de Canarias, Santa Cruz de Tenerife, España | |
dc.ucuenca.afiliacion | González, A., Universidad Cardenal Herrera CEU (Valencia), Valencia, España | |
dc.ucuenca.afiliacion | Bassols, A., Universitat Autónoma de Barcelona UAB, Barcelona, España | |
dc.ucuenca.correspondencia | Bassols, Ana, anna.bassols@uab.cat | |
dc.ucuenca.volumen | Volumen 14, número 16 | |
dc.ucuenca.indicebibliografico | SCOPUS | |
dc.ucuenca.factorimpacto | 1.287 | |
dc.ucuenca.cuartil | Q1 | |
dc.ucuenca.numerocitaciones | 0 | |
dc.ucuenca.areaconocimientofrascatiamplio | 4. Ciencias Agrícolas | |
dc.ucuenca.areaconocimientofrascatiespecifico | 4.3 Medicina Veterinaria | |
dc.ucuenca.areaconocimientofrascatidetallado | 4.3.1 Ciencias veterinarias | |
dc.ucuenca.areaconocimientounescoespecifico | 084 - Veterinaria | |
dc.ucuenca.areaconocimientounescodetallado | 0841 - Veterinaria | |
dc.ucuenca.urifuente | https://www.mdpi.com/ | |
Appears in Collections: | Artículos |
Files in This Item:
File | Size | Format | |
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documento.pdf | 3.16 MB | Adobe PDF | View/Open |
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