Frecuencia de positividad de anticuerpos anti péptido citrulinados en enfermedades autoinmunes de pacientes del Hospital Vicente Corral Moscoso, año 2019

Abstract

BACKGROUND: Autoimmune diseases are characterized by not distinguishing antigens from antibodies, thus generating a counterattack against the body itself in wich the patient´s health is impaired. For this reason, the detection of anticitrullinated peptide (anti-CCP) antibodies has clinical importance for the identification of rheumatoid arthritis, however, in many studies it has been related to other autoimmune diseases, in which its presence is associated with joint damage in early stages that has allowed the patient to opt for timely and effective treatment. GENERAL OBJETIVE: To determine the frequency of positivity of anticitrullinated peptide antibodies in autoimmune diseases of patients at the Vicente Corral Moscoso Hospital, year 2019. METHODOLOGY: This study was descriptive, cross-sectional. The data was collected through forms, and tabulated in the SPSS V26 and Microsoft Excel program, through simple tables for the variables as: age, sex, origin and autoimmune disease were obtained, and cross tables were used for the association of the variable raised with the variable anti-CCP antibodies, thus obtaining the results of frequency and their respective interpretation. RESULTS: A total of 439 patients were registered of which 126 (28.7%) tested positive for anti-CCP antibodies. The largest number of cases was between the ages of 41 to 50 years n=36 (8.2%), predominantly female n=101 (23%), originating from the province of Azuay n=71 (16.2%). Of the 126 positive patients, 87.3% had a diagnosis of rheumatoid arthritis. CONCLUSIONS: The positivity of anti-CCP is more frequent in adult women with rheumatoid arthritis, however, its presence was also evidenced in other pathologies as indicative of joint damage