Nalbufina, bupivacaina, y su combinación para el control del dolor en pacientes sometidos a colecistectomía laparoscópica, Hospital Vicente Corral Moscoso, Cuenca 2010

Abstract

Acute pain post-laparoscopic cholecystectomy is complex and different assessment, however the goal of treatment should be to get the comfort of patients undergoing surgical procedures.

Objective: To determine the Nalbuphine and Bupivacaine preincisional periportal infiltration efficacy in patients undergoing laparoscopic cholecystectomy.

Methodology: A randomized single-blind experimental study was performed, 99 patients are included, which compared the Bupivacaine and Nalbuphine effect with their separate effects in patients undergoing laparoscopic cholecystectomy. Three groups sere formed: A receiving Nalbuphine 10 mg intravenous preincisional, in B group, bupivacaine 0.25% periportal infiltration was administered, and C group (experimental group), receiving the combination 10 mg of Nalbuphine preincisional and bupivacaine periportal infiltration. The pain was assessed by visual analogue scale (VAS) using Nalbuphine as an analgesic supplement.

Results: The Nalbuphine group had less pain than the experimental group and especially the buoivacaine group, so the Bupivacaine need more supplementary doses of analgesia (2.88 ± 0.89) on the Nalbuphine ( 1.55 ± 0.71) and experimental group (2.12 ± 0.78).

Conclusions: Preemptive analgesia with Nalbuphine obtains better scores in comparison to Nalbuphine and bupivacaine combination. Bupivacaine alone does not have good results on pain control postcholecystectomy laparoscopy, and need more supplementary doses of analgesia

Key words: Nalbuphine, Bupivacaine, Laparoscopic cholecystectomy, postoperative pain, patient controlled analgesia