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DC Field | Value | Language |
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dc.contributor.author | Lopez Cisneros, Carmen Lucia | |
dc.contributor.author | Cazar Ramirez, Maria Elena | |
dc.contributor.author | Bailon Moscoso, Natalia | |
dc.contributor.author | Guardado, Estela | |
dc.contributor.author | Borges, Fernanda | |
dc.contributor.author | Uriarte, Eugenio | |
dc.contributor.author | Matos, Maria JoAo | |
dc.date.accessioned | 2021-11-12T00:01:13Z | - |
dc.date.available | 2021-11-12T00:01:13Z | - |
dc.date.issued | 2021 | |
dc.identifier.issn | 2365-6549 | |
dc.identifier.uri | https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202103099 | |
dc.description.abstract | The main etiological agents in dermatophytosis of human skin and nails are Trichophyton, in particular Trichophyton rubrum (T. rubrum) and Trichophyton mentagrophytes (T. mentagro- phytes). A new series of twenty-three 3- and 4-arylcoumarins was synthesized and the antifungal activities against clinical isolates of T. rubrum and T. mentagrophytes were evaluated. Sixteen out of twenty-three molecules exhibited antifungal activity against one or both fungi strains. In some cases, the activity against T. rubrum has been comparable to fluconazole, one of the standards, being 8-methoxy-3-(4’-nitrophenyl) coumarin (16) the best compound within this series (minimum inhibitory concentration, MIC=6.25 μg/mL). The preliminary structure-activity relationship study showed that the antifungal activity depends on the position and nature of the substitution patterns. The cytotoxicity of eleven compounds on D-384 (astrocytoma), A-549 (lung cancer) and RKO (colorectal cancer) cell lines was also performed. With the aim of deeply under- stand the potential of these molecules as hits to develop new drugs, the theoretical absorption, distribution, metabolism and excretion (ADME) properties of the active compounds were calculated | |
dc.language.iso | es_ES | |
dc.source | Chemistry Select | |
dc.subject | Arylcoumarins | |
dc.subject | Antifungal agents | |
dc.subject | Heterocycles | |
dc.subject | Synthesis | |
dc.title | Study of a selected series of 3- and 4-arylcoumarins as antifungal agents against dermatophytic fungi: T. rubrum and T. mentagrophytes | |
dc.type | ARTÍCULO | |
dc.ucuenca.idautor | 0102173952 | |
dc.ucuenca.idautor | 0602243800 | |
dc.ucuenca.idautor | 0000-0003-2754-1328 | |
dc.ucuenca.idautor | 0000-0002-0515-6720 | |
dc.ucuenca.idautor | 0000-0003-1050-2402 | |
dc.ucuenca.idautor | 0000-0001-6218-2899 | |
dc.ucuenca.idautor | 0000-0002-3470-8299 | |
dc.identifier.doi | 10.1002/slct.202103099 | |
dc.ucuenca.version | Versión publicada | |
dc.ucuenca.areaconocimientounescoamplio | 05 - Ciencias Físicas, Ciencias Naturales, Matemáticas y Estadísticas | |
dc.ucuenca.afiliacion | Lopez, C., Universidad de Cuenca, Departamento de Química Aplicada y Sistemas de Producción, Cuenca, Ecuador | |
dc.ucuenca.afiliacion | Cazar, M., Universidad de Cuenca, Departamento de Química Aplicada y Sistemas de Producción, Cuenca, Ecuador | |
dc.ucuenca.afiliacion | Bailon, N., Universidad Técnica Particular de Loja (UTPL), Loja, Ecuador | |
dc.ucuenca.afiliacion | Guardado, E., Universidad Estatal Amazónica, Puyo, Ecuador | |
dc.ucuenca.afiliacion | Borges, F., Universidade do Porto, Porto, Portugal | |
dc.ucuenca.afiliacion | Uriarte, E., Universidad de Santiago de Compostela, Santiago de Compostela, España | |
dc.ucuenca.afiliacion | Matos, M., Universidad de Santiago de Compostela, Santiago de Compostela, España | |
dc.ucuenca.correspondencia | Matos, Maria JoAo, mariajoao.correiapinto@usc.es | |
dc.ucuenca.volumen | Volumen 6, número 37 | |
dc.ucuenca.indicebibliografico | SCOPUS | |
dc.ucuenca.factorimpacto | 0.437 | |
dc.ucuenca.cuartil | Q2 | |
dc.ucuenca.numerocitaciones | 0 | |
dc.ucuenca.areaconocimientofrascatiamplio | 1. Ciencias Naturales y Exactas | |
dc.ucuenca.areaconocimientofrascatiespecifico | 1.4 Ciencias Químicas | |
dc.ucuenca.areaconocimientofrascatidetallado | 1.4.1 Química Orgánica | |
dc.ucuenca.areaconocimientounescoespecifico | 051 - Ciencias Biológicas y Afines | |
dc.ucuenca.areaconocimientounescodetallado | 0512 - Bioquímica | |
dc.ucuenca.urifuente | https://chemistry-europe.onlinelibrary.wiley.com/toc/23656549/2021/6/37 | |
Appears in Collections: | Artículos |
Files in This Item:
File | Size | Format | |
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documento.pdf | 2.49 MB | Adobe PDF | View/Open |
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