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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Ortiz Sanchez, Elizabeth | - |
dc.contributor.author | Toledo Guzmán, María Esperanza | - |
dc.contributor.author | Bigoni Ordoñez, Gabriele Davide | - |
dc.contributor.author | Ibañez Fernández, Miguel | - |
dc.date.accessioned | 2021-05-19T14:31:58Z | - |
dc.date.available | 2021-05-19T14:31:58Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1948-0210 | - |
dc.identifier.uri | http://dspace.ucuenca.edu.ec/handle/123456789/36187 | - |
dc.identifier.uri | https://www.wjgnet.com/1948-0210/full/v10/i12/183.htm | - |
dc.description.abstract | Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate from cancer corre- lates with a lack of clear symptoms, which results in late diagnosis for patients, and consequently, advanced tumor disease with poor probabilities for cure, since many patients will show chemo- and radio-resistance. Several mechanisms have been studied to explain chemo- and radio-resistance to anti-tumor therapies, including cell signaling pathways, anti-apoptotic mecha- nisms, stemness, metabolism, and cellular phenotypes. Interestingly, the presence of cancer stem cells (CSCs), which are a subset of cells within the tumors, has been related to therapy resistance. In this review, we focus on evaluating the presence of CSCs in different tumors such as breast cancer, gastric cancer, lung cancer, and hematological neoplasias, highlighting studies where CSCs were identified in patient samples. It is evident that there has been a great drive to identify the cell surface phenotypes of CSCs so that they can be used as a tool for anti-tumor therapy treatment design. We also review the potential effect of nanoparticles, drugs, natural compounds, aldehyde dehydrogenase inhibitors, cell signaling inhibitors, and antibodies to treat CSCs from specific tumors. Taken together, we present an overview of the role of CSCs in tumorigenesis and how research is advancing to target these highly tumorigenic cells to improve oncology patient outcomes. | - |
dc.language.iso | es_ES | - |
dc.source | World Journal of Stem Cell | - |
dc.subject | Drug resistance | - |
dc.subject | Cancer | - |
dc.subject | Targeted therapy | - |
dc.subject | Clinical outcome | - |
dc.subject | Cancer stem cells | - |
dc.title | Cancer stem cell impact on clinical oncology | - |
dc.type | ARTÍCULO | - |
dc.ucuenca.idautor | 1711901429 | - |
dc.ucuenca.idautor | 0003-4992-8486 | - |
dc.ucuenca.idautor | 0003-4013-6888 | - |
dc.ucuenca.idautor | 0001-9855-9491 | - |
dc.identifier.doi | 10.4252/wjsc.v10.i12.183] | - |
dc.ucuenca.version | Versión publicada | - |
dc.ucuenca.areaconocimientounescoamplio | 05 - Ciencias Físicas, Ciencias Naturales, Matemáticas y Estadísticas | - |
dc.ucuenca.afiliacion | Toledo, M., Instituto Politecnico Nacional, Mexico City, Mexico | - |
dc.ucuenca.afiliacion | Bigoni, G., Universidad Nacional Autonoma de Mexico, Mexico City, Mexico; Bigoni, G., Universidad de Cuenca, Facultad de Ciencias Médicas, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Ibañez, M., Instituto Politecnico Nacional, Mexico City, Mexico | - |
dc.ucuenca.afiliacion | Ortiz, E., Centro Estatal de Cancerología, Durango, Mexico | - |
dc.ucuenca.volumen | Volume 10, número 12 | - |
dc.ucuenca.indicebibliografico | SCOPUS | - |
dc.ucuenca.factorimpacto | 0.91 | - |
dc.ucuenca.cuartil | Q2 | - |
dc.ucuenca.numerocitaciones | 978 | - |
dc.ucuenca.areaconocimientofrascatiamplio | 1. Ciencias Naturales y Exactas | - |
dc.ucuenca.areaconocimientofrascatiespecifico | 1.6 Ciencias Biológicas | - |
dc.ucuenca.areaconocimientofrascatidetallado | 1.6.1 Biología Celular | - |
dc.ucuenca.areaconocimientounescoespecifico | 051 - Ciencias Biológicas y Afines | - |
dc.ucuenca.areaconocimientounescodetallado | 0511 - Biología | - |
dc.ucuenca.urifuente | https://www.wjgnet.com/1948-0210/index.htm | - |
Appears in Collections: | Artículos |
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documento.pdf | document | 862.63 kB | Adobe PDF | View/Open |
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