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Please use this identifier to cite or link to this item: http://dspace.ucuenca.edu.ec/handle/123456789/34243
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dc.contributor.authorCuzco Quizhpi, Nancy Mirian
dc.contributor.authorWilches Arizabala, Isabel Maria
dc.contributor.authorVila Calsina, Elisabet Null
dc.contributor.authorLeon Tamariz, Fabian
dc.contributor.authorJimenez Castillo, Priscilla Yazmin
dc.contributor.authorVander Heyden, Yvan
dc.contributor.authorTobar Solano, Vladimiro Alexis
dc.contributor.authorJerves Andrade, Maria De lourdes
dc.contributor.authorPeñaherrera Wilches, Eugenia
dc.contributor.authorJiménez Altayó, Francesc
dc.contributor.authorClos, Victoria
dc.date.accessioned2020-05-08T00:21:54Z-
dc.date.available2020-05-08T00:21:54Z-
dc.date.issued2019
dc.identifier.issn1478-6419
dc.identifier.urihttp://dspace.ucuenca.edu.ec/handle/123456789/34243-
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066777908&origin=inward
dc.descriptionAerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use.
dc.description.abstract© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use.
dc.language.isoes_ES
dc.sourceNatural Product Research
dc.subjectmice models
dc.subjectanti-inflammatory
dc.subjectAnti-inflammatory
dc.subjectPeperomia galioides
dc.subjectsedative activity
dc.subjectPeperomia galioides
dc.subjectmice models
dc.subjectSedative activity
dc.titleAnti-inflammatory and sedative activities of Peperomia galioides: in vivo studies in mice
dc.typeARTÍCULO
dc.ucuenca.idautor0102311610
dc.ucuenca.idautor0301624854
dc.ucuenca.idautor0000-0002-7389-3351
dc.ucuenca.idautor0000-0002-9034-2041
dc.ucuenca.idautor0102452075
dc.ucuenca.idautor0101660579
dc.ucuenca.idautor1104122765
dc.ucuenca.idautor0300969334
dc.ucuenca.idautor0000-0002-7788-9886
dc.ucuenca.idautor0102286549
dc.ucuenca.idautorAAH961467
dc.identifier.doi10.1080/14786419.2019.1622104
dc.ucuenca.embargoend2050-12-31
dc.ucuenca.versionVersión publicada
dc.ucuenca.embargointerno2050-12-31
dc.ucuenca.areaconocimientounescoamplio05 - Ciencias Físicas, Ciencias Naturales, Matemáticas y Estadísticas
dc.ucuenca.afiliacionJimenez, P., Universidad de Cuenca, Facultad de Ciencias Químicas, Cuenca, Ecuador
dc.ucuenca.afiliacionVila, E., Universidad de Cuenca, Cuenca, Ecuador; Vila, E., Universitat de Barcelona, Barcelona, España
dc.ucuenca.afiliacionWilches, I., Universidad de Cuenca, Facultad de Ciencias Químicas, Cuenca, Ecuador
dc.ucuenca.afiliacionLeon, F., Universidad de Cuenca, Cuenca, Ecuador
dc.ucuenca.afiliacionVander, Y., Vrije Universiteit Brussel, Elsene, Belgica
dc.ucuenca.afiliacionTobar, V., Universidad de Cuenca, Cuenca, Ecuador
dc.ucuenca.afiliacionJerves, M., Universidad de Cuenca, Cuenca, Ecuador
dc.ucuenca.afiliacionPeñaherrera, E., Universidad de Cuenca, Cuenca, Ecuador
dc.ucuenca.afiliacionJiménez, F., Universitat de Barcelona, Barcelona, España
dc.ucuenca.afiliacionClos, V., Universitat de Barcelona, Barcelona, España
dc.ucuenca.afiliacionCuzco, N., Universidad de Cuenca, Facultad de Ciencias Químicas, Cuenca, Ecuador
dc.ucuenca.correspondenciaVila Calsina, Elisabet Null, elisabet.vila@uab.cat
dc.ucuenca.volumenVolumen 0
dc.ucuenca.indicebibliograficoSCOPUS
dc.ucuenca.factorimpacto0.6
dc.ucuenca.cuartilQ2
dc.ucuenca.numerocitaciones0
dc.ucuenca.areaconocimientofrascatiamplio1. Ciencias Naturales y Exactas
dc.ucuenca.areaconocimientofrascatiespecifico1.4 Ciencias Químicas
dc.ucuenca.areaconocimientofrascatidetallado1.4.1 Química Orgánica
dc.ucuenca.areaconocimientounescoespecifico051 - Ciencias Biológicas y Afines
dc.ucuenca.areaconocimientounescodetallado0512 - Bioquímica
dc.ucuenca.urifuentehttps://www.tandfonline.com/toc/gnpl20/current
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