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http://dspace.ucuenca.edu.ec/handle/123456789/34243
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DC Field | Value | Language |
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dc.contributor.author | Jiménez Altayó, Francesc | - |
dc.contributor.author | Wilches Arizabala, Isabel Maria | - |
dc.contributor.author | Jimenez Castillo, Priscilla Yazmin | - |
dc.contributor.author | Cuzco Quizhpi, Nancy Mirian | - |
dc.contributor.author | Clos, Victoria | - |
dc.contributor.author | Peñaherrera Wilches, Eugenia | - |
dc.contributor.author | Jerves Andrade, Maria De lourdes | - |
dc.contributor.author | Tobar Solano, Vladimiro Alexis | - |
dc.contributor.author | Vander Heyden, Yvan | - |
dc.contributor.author | Leon Tamariz, Fabian | - |
dc.contributor.author | Vila Calsina, Elisabet Null | - |
dc.date.accessioned | 2020-05-08T00:21:54Z | - |
dc.date.available | 2020-05-08T00:21:54Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1478-6419 | - |
dc.identifier.uri | http://dspace.ucuenca.edu.ec/handle/123456789/34243 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066777908&origin=inward | - |
dc.description | Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use. | - |
dc.description.abstract | © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use. | - |
dc.language.iso | es_ES | - |
dc.source | Natural Product Research | - |
dc.subject | Sedative activity | - |
dc.subject | Peperomia galioides | - |
dc.subject | sedative activity | - |
dc.subject | Anti-inflammatory | - |
dc.subject | mice models | - |
dc.subject | anti-inflammatory | - |
dc.subject | mice models | - |
dc.subject | Peperomia galioides | - |
dc.title | Anti-inflammatory and sedative activities of Peperomia galioides: in vivo studies in mice | - |
dc.type | ARTÍCULO | - |
dc.ucuenca.idautor | 1104122765 | - |
dc.ucuenca.idautor | 0301624854 | - |
dc.ucuenca.idautor | 0000-0002-7389-3351 | - |
dc.ucuenca.idautor | 0000-0002-9034-2041 | - |
dc.ucuenca.idautor | 0102452075 | - |
dc.ucuenca.idautor | 0101660579 | - |
dc.ucuenca.idautor | 0300969334 | - |
dc.ucuenca.idautor | 0000-0002-7788-9886 | - |
dc.ucuenca.idautor | 0102311610 | - |
dc.ucuenca.idautor | AAH961467 | - |
dc.ucuenca.idautor | 0102286549 | - |
dc.identifier.doi | 10.1080/14786419.2019.1622104 | - |
dc.ucuenca.embargoend | 2050-12-31 | - |
dc.ucuenca.version | Versión publicada | - |
dc.ucuenca.embargointerno | 2050-12-31 | - |
dc.ucuenca.areaconocimientounescoamplio | 05 - Ciencias Físicas, Ciencias Naturales, Matemáticas y Estadísticas | - |
dc.ucuenca.afiliacion | Jiménez, F., Universitat de Barcelona, Barcelona, España | - |
dc.ucuenca.afiliacion | Tobar, V., Universidad de Cuenca, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Jerves, M., Universidad de Cuenca, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Peñaherrera, E., Universidad de Cuenca, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Cuzco, N., Universidad de Cuenca, Facultad de Ciencias Químicas, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Jimenez, P., Universidad de Cuenca, Facultad de Ciencias Químicas, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Leon, F., Universidad de Cuenca, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Wilches, I., Universidad de Cuenca, Facultad de Ciencias Químicas, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Clos, V., Universitat de Barcelona, Barcelona, España | - |
dc.ucuenca.afiliacion | Vila, E., Universidad de Cuenca, Cuenca, Ecuador; Vila, E., Universitat de Barcelona, Barcelona, España | - |
dc.ucuenca.afiliacion | Vander, Y., Vrije Universiteit Brussel, Elsene, Belgica | - |
dc.ucuenca.correspondencia | Vila Calsina, Elisabet Null, elisabet.vila@uab.cat | - |
dc.ucuenca.volumen | Volumen 0 | - |
dc.ucuenca.indicebibliografico | SCOPUS | - |
dc.ucuenca.factorimpacto | 0.6 | - |
dc.ucuenca.cuartil | Q2 | - |
dc.ucuenca.numerocitaciones | 0 | - |
dc.ucuenca.areaconocimientofrascatiamplio | 1. Ciencias Naturales y Exactas | - |
dc.ucuenca.areaconocimientofrascatiespecifico | 1.4 Ciencias Químicas | - |
dc.ucuenca.areaconocimientofrascatidetallado | 1.4.1 Química Orgánica | - |
dc.ucuenca.areaconocimientounescoespecifico | 051 - Ciencias Biológicas y Afines | - |
dc.ucuenca.areaconocimientounescodetallado | 0512 - Bioquímica | - |
dc.ucuenca.urifuente | https://www.tandfonline.com/toc/gnpl20/current | - |
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