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Título : Anti-inflammatory and sedative activities of Peperomia galioides: in vivo studies in mice
Autor: Cuzco Quizhpi, Nancy Mirian
Wilches Arizabala, Isabel Maria
Vila Calsina, Elisabet Null
Leon Tamariz, Fabian
Jimenez Castillo, Priscilla Yazmin
Vander Heyden, Yvan
Tobar Solano, Vladimiro Alexis
Jerves Andrade, Maria De lourdes
Peñaherrera Wilches, Eugenia
Jiménez Altayó, Francesc
Clos, Victoria
Correspondencia: Vila Calsina, Elisabet Null, elisabet.vila@uab.cat
Palabras clave : mice models
anti-inflammatory
Anti-inflammatory
Peperomia galioides
sedative activity
Peperomia galioides
mice models
Sedative activity
Area de conocimiento FRASCATI amplio: 1. Ciencias Naturales y Exactas
Area de conocimiento FRASCATI detallado: 1.4.1 Química Orgánica
Area de conocimiento FRASCATI específico: 1.4 Ciencias Químicas
Area de conocimiento UNESCO amplio: 05 - Ciencias Físicas, Ciencias Naturales, Matemáticas y Estadísticas
Area de conocimiento UNESCO detallado: 0512 - Bioquímica
Area de conocimiento UNESCO específico: 051 - Ciencias Biológicas y Afines
Fecha de publicación : 2019
Fecha de fin de embargo: 31-dic-2050
Volumen: Volumen 0
Fuente: Natural Product Research
metadata.dc.identifier.doi: 10.1080/14786419.2019.1622104
Tipo: ARTÍCULO
Abstract: 
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group. Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use.
Resumen : 
Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used to confirm its anti-inflammatory and sedative folk uses. The anti-inflammatory activity was assessed by croton oil-induced ear oedema and myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) and Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). The sedative activity was studied by the pentobarbital-induced sleeping time test. Single doses (300 and 600 mg/kg; i.p.) of the extract reduced croton oil-induced ear oedema and myeloperoxidase activity. Six days administration of the extract (300 mg/kg, i.p.) to mice implanted with cotton pellets diminished granuloma formation. LPS (20 mg/kg, i.p.) enhanced plasma nitrites and TNF-α levels that were inhibited by the extract. The duration but not the onset of sleeping time was enhanced by 300 and 600 mg/kg of the extract. Our results show that P. galioides has anti-inflammatory and sedative activities in mice, which validates its traditional use.
URI : http://dspace.ucuenca.edu.ec/handle/123456789/34243
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85066777908&origin=inward
URI Fuente: https://www.tandfonline.com/toc/gnpl20/current
ISSN : 1478-6419
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