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dc.contributor.authorGarcía Contreras, Consolación
dc.contributor.authorVázquez Gómez, Marta
dc.contributor.authorPesantez Pacheco, Jose Luis
dc.contributor.authorTorres Rovira, Laura
dc.contributor.authorHeras Molina, Ana
dc.contributor.authorEncinas, Teresa
dc.contributor.authorAstiz, Susana
dc.contributor.authorGonzález Bulnes, Antonio
dc.date.accessioned2019-09-12T17:19:58Z-
dc.date.available2019-09-12T17:19:58Z-
dc.date.issued2019
dc.identifier.issn2218-273X
dc.identifier.urihttp://dspace.ucuenca.edu.ec/handle/123456789/33396-
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pubmed/31035702
dc.descriptionMetformin is an anti-hyperglycemic drug widely used for the treatment of insulin resistance and glucose intolerance and is currently considered for preventing large-for-gestational-age (LGA) o spring in pregnant women a ected by obesity or diabetes. Our hypothesis was the opposite—metformin may be used for improving the development of o spring a ected by intrauterine growth restriction (IUGR) and preventing the appearance of small-for-gestational-age (SGA) neonates in non-obese and non-diabetic but malnourished pregnancies. The current study, performed in a swine preclinical model of IUGR by undernutrition, showed that fetuses in the treated group showed no significant increases in body-weight, but showed a significantly higher weight of the brain, the total thoracic and abdominal viscera, the liver, the kidneys, the spleen, and the adrenal glands. Maternal metformin treatment was also related to significant increases in the fetal plasma concentration of parameters indicative of glycemic (glucose and fructosamine) and lipid profiles (triglycerides). Overall, these results suggest a protective e ect of the treatment on the developmental competence of the fetuses. These findings may be of high value for human medicine in case of maternal malnutrition, since metformin is a cheap drug easily available, but also in case of placental deficiency, since metformin seems to improve placental development and function.
dc.description.abstractMetformin is an anti-hyperglycemic drug widely used for the treatment of insulin resistance and glucose intolerance and is currently considered for preventing large-for-gestational-age (LGA) o spring in pregnant women a ected by obesity or diabetes. Our hypothesis was the opposite—metformin may be used for improving the development of o spring a ected by intrauterine growth restriction (IUGR) and preventing the appearance of small-for-gestational-age (SGA) neonates in non-obese and non-diabetic but malnourished pregnancies. The current study, performed in a swine preclinical model of IUGR by undernutrition, showed that fetuses in the treated group showed no significant increases in body-weight, but showed a significantly higher weight of the brain, the total thoracic and abdominal viscera, the liver, the kidneys, the spleen, and the adrenal glands. Maternal metformin treatment was also related to significant increases in the fetal plasma concentration of parameters indicative of glycemic (glucose and fructosamine) and lipid profiles (triglycerides). Overall, these results suggest a protective e ect of the treatment on the developmental competence of the fetuses. These findings may be of high value for human medicine in case of maternal malnutrition, since metformin is a cheap drug easily available, but also in case of placental deficiency, since metformin seems to improve placental development and function.
dc.language.isoes_ES
dc.sourceBiomolecules
dc.subjectIntrauterine-Growth-Restriction
dc.subjectMetformin
dc.subjectPregnancy
dc.subjectSwine-Model
dc.titleMaternal metformin treatment improves developmental and metabolic traits of IUGR fetuses
dc.typeARTÍCULO
dc.ucuenca.idautorSgrp-1923-1
dc.ucuenca.idautorSgrp-1922-2
dc.ucuenca.idautor0104911193
dc.ucuenca.idautorSgrp-1922-4
dc.ucuenca.idautorSgrp-1922-5
dc.ucuenca.idautorSgrp-1922-6
dc.ucuenca.idautorSgrp-1922-7
dc.ucuenca.idautorSgrp-1922-8
dc.identifier.doi10.3390/biom9050166
dc.ucuenca.versionVersión publicada
dc.ucuenca.areaconocimientounescoamplio08 - Agricultura, Silvicultura, Pesca y Veterinaria
dc.ucuenca.afiliacionGarcía, C., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionVázquez, M., Universidad Complutense de Madrid, Madrid, España
dc.ucuenca.afiliacionPesantez, J., Universidad de Cuenca, Facultad de Ciencias Agropecuarias, Cuenca, Ecuador
dc.ucuenca.afiliacionTorres, L., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionHeras, A., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionEncinas, T., Universidad Complutense de Madrid, Madrid, España
dc.ucuenca.afiliacionAstiz, S., Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (Madrid), Madrid, España
dc.ucuenca.afiliacionGonzález, A., Universidad Complutense de Madrid, Madrid, España
dc.ucuenca.correspondenciaGonzález Bulnes, Antonio, bulnes@inia.es
dc.ucuenca.volumenvolume 9, issue 5
dc.ucuenca.indicebibliograficoSCOPUS
dc.ucuenca.factorimpacto2.525
dc.ucuenca.cuartilQ1
dc.ucuenca.numerocitaciones0
dc.ucuenca.areaconocimientofrascatiamplio4. Ciencias Agrícolas
dc.ucuenca.areaconocimientofrascatiespecifico4.2 Zootecnia y Ciencia de los Lácteos
dc.ucuenca.areaconocimientofrascatidetallado4.2.2 Ganaderia: Mascotas
dc.ucuenca.areaconocimientounescoespecifico084 - Veterinaria
dc.ucuenca.areaconocimientounescodetallado0841 - Veterinaria
dc.ucuenca.urifuentehttps://www.mdpi.com/journal/biomolecules
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