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Título : Maternal metformin treatment improves developmental and metabolic traits of IUGR fetuses
Autor: García Contreras, Consolación
Vázquez Gómez, Marta
Pesantez Pacheco, Jose Luis
Torres Rovira, Laura
Heras Molina, Ana
Encinas, Teresa
Astiz, Susana
González Bulnes, Antonio
Correspondencia: González Bulnes, Antonio, bulnes@inia.es
Palabras clave : Intrauterine-Growth-Restriction
Metformin
Pregnancy
Swine-Model
Area de conocimiento FRASCATI amplio: 4. Ciencias Agrícolas
Area de conocimiento FRASCATI detallado: 4.2.2 Ganaderia: Mascotas
Area de conocimiento FRASCATI específico: 4.2 Zootecnia y Ciencia de los Lácteos
Area de conocimiento UNESCO amplio: 08 - Agricultura, Silvicultura, Pesca y Veterinaria
Area de conocimiento UNESCO detallado: 0841 - Veterinaria
Area de conocimiento UNESCO específico: 084 - Veterinaria
Fecha de publicación : 2019
Volumen: volume 9, issue 5
Fuente: Biomolecules
metadata.dc.identifier.doi: 10.3390/biom9050166
Tipo: ARTÍCULO
Abstract: 
Metformin is an anti-hyperglycemic drug widely used for the treatment of insulin resistance and glucose intolerance and is currently considered for preventing large-for-gestational-age (LGA) o spring in pregnant women a ected by obesity or diabetes. Our hypothesis was the opposite—metformin may be used for improving the development of o spring a ected by intrauterine growth restriction (IUGR) and preventing the appearance of small-for-gestational-age (SGA) neonates in non-obese and non-diabetic but malnourished pregnancies. The current study, performed in a swine preclinical model of IUGR by undernutrition, showed that fetuses in the treated group showed no significant increases in body-weight, but showed a significantly higher weight of the brain, the total thoracic and abdominal viscera, the liver, the kidneys, the spleen, and the adrenal glands. Maternal metformin treatment was also related to significant increases in the fetal plasma concentration of parameters indicative of glycemic (glucose and fructosamine) and lipid profiles (triglycerides). Overall, these results suggest a protective e ect of the treatment on the developmental competence of the fetuses. These findings may be of high value for human medicine in case of maternal malnutrition, since metformin is a cheap drug easily available, but also in case of placental deficiency, since metformin seems to improve placental development and function.
Resumen : 
Metformin is an anti-hyperglycemic drug widely used for the treatment of insulin resistance and glucose intolerance and is currently considered for preventing large-for-gestational-age (LGA) o spring in pregnant women a ected by obesity or diabetes. Our hypothesis was the opposite—metformin may be used for improving the development of o spring a ected by intrauterine growth restriction (IUGR) and preventing the appearance of small-for-gestational-age (SGA) neonates in non-obese and non-diabetic but malnourished pregnancies. The current study, performed in a swine preclinical model of IUGR by undernutrition, showed that fetuses in the treated group showed no significant increases in body-weight, but showed a significantly higher weight of the brain, the total thoracic and abdominal viscera, the liver, the kidneys, the spleen, and the adrenal glands. Maternal metformin treatment was also related to significant increases in the fetal plasma concentration of parameters indicative of glycemic (glucose and fructosamine) and lipid profiles (triglycerides). Overall, these results suggest a protective e ect of the treatment on the developmental competence of the fetuses. These findings may be of high value for human medicine in case of maternal malnutrition, since metformin is a cheap drug easily available, but also in case of placental deficiency, since metformin seems to improve placental development and function.
URI : http://dspace.ucuenca.edu.ec/handle/123456789/33396
https://www.ncbi.nlm.nih.gov/pubmed/31035702
URI Fuente: https://www.mdpi.com/journal/biomolecules
ISSN : 2218-273X
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