Please use this identifier to cite or link to this item: http://dspace.ucuenca.edu.ec/handle/123456789/33316
Title: Polyphenols and iugr pregnancies: effects of maternal hydroxytyrosol supplementation on placental gene expression and fetal antioxidant status, dna-methylation and phenotype
Other Titles: 
Authors: García Contreras, Consolación
Vázquez Gómez, Marta
Barbero Fernández, Alicia
Pesantez Pacheco, Jose Luis
Zinellu, Angelo
Berlinguer, Fiammetta
González Añover, Pedro
González, Jorge Ernesto
Encinas, Teresa
Torres Rovira, Laura
Nuñez, Yolanda
Ballesteros, Jaime
Ayuso, Miriam
Astiz, Susana
Isabel, Beatriz
González Bulnes, Antonio
Keywords: Antioxidants
Intrauterine-growth-restriction
Pregnancy
Swine-model
Issue Date: 2019
metadata.dc.type: ARTÍCULO
Abstract: 
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
Description: 
The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found. © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
URI: http://dspace.ucuenca.edu.ec/handle/123456789/33316
https://www.scopus.com/record/display.uri?eid=2-s2.0-85062873820&doi=10.3390%2fijms20051187&origin=inward&txGid=341173c5c469de73a64c196cbdacfac2
ISSN: 1661-6596, 1422-0067 (e)
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