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Please use this identifier to cite or link to this item: http://dspace.ucuenca.edu.ec/handle/123456789/33119
Title: Cardiac autonomic modulation in response to a glucose stimulus
Authors: Perpiñan, Gilberto
Severeyn, Erika
Wong de balzan , Sara Null
Altuve, Miguel
metadata.dc.ucuenca.correspondencia: Perpiñan, Gilberto, gilberto.perpinan@uan.edu.co
Keywords: Electrocardiogram
Frequency-Domain Analysis
Heart Rate Variability
Time-Domain Analysis
metadata.dc.ucuenca.areaconocimientofrascatiamplio: 3. Ciencias Médicas y de la Salud
metadata.dc.ucuenca.areaconocimientofrascatidetallado: 3.2.4 Sistema Cardíaco y Cardiovascular
metadata.dc.ucuenca.areaconocimientofrascatiespecifico: 3.2 Medicina Clínica
metadata.dc.ucuenca.areaconocimientounescoamplio: 09 - Salud y Bienestar
metadata.dc.ucuenca.areaconocimientounescodetallado: 0914 - Tecnologías de Diagnóstico y Tratamiento Médico
metadata.dc.ucuenca.areaconocimientounescoespecifico: 091 - Salud
Issue Date: 2018
metadata.dc.ucuenca.volumen: volumen 57, número 3
metadata.dc.source: Medical and biological engineering
metadata.dc.identifier.doi: 10.1007/s11517-018-1913-1
metadata.dc.type: ARTÍCULO
Abstract: 
This paper focuses on the effect of a sudden increase of plasma glucose concentration in the cardiac autonomic modulation using time-domain and frequency-domain heart rate variability (HRV) measures. Plasma glucose and insulin levels, measured each 30 min during an oral glucose tolerance test, and RR ¯ $\overline {\text {RR}}$ (mean of the RR interval), SDNN (standard deviation of normal-to-normal heartbeats), rMSSD (root-mean-square of successive differences between normal heartbeats), TP (total spectral power), LF and HF (power of the low- and high-frequency bands), LF norm and HF norm (LF and HF in normalized units), and LF/HF ratio of the HRV signal, obtained from 5-min-long ECG recordings during each phase of the test, were analyzed for subjects with the metabolic syndrome, marathon runners, and a control group. Results show that, after the glucose load, subjects with the metabolic syndrome experienced an increased sympathetic and decreased parasympathetic tone, which suggests an imbalance in cardiac autonomic modulation as a consequence of hyperglycemia and hyperinsulinemia. The significance of this study lies in the use of the ECG to assess the effects of a sudden increase in plasma glucose concentration on the cardiac autonomic modulation in subjects with different cardiovascular and metabolic conditions. Graphical Abstract Time-domain and frequency-domain heart rate variability measures are altered in subjects with different cardiovascular and metabolic conditions during an oral glucose tolerance test
Description: 
This paper focuses on the effect of a sudden increase of plasma glucose concentration in the cardiac autonomic modulation using time-domain and frequency-domain heart rate variability (HRV) measures. Plasma glucose and insulin levels, measured each 30 min during an oral glucose tolerance test, and RR ¯ $\overline {\text {RR}}$ (mean of the RR interval), SDNN (standard deviation of normal-to-normal heartbeats), rMSSD (root-mean-square of successive differences between normal heartbeats), TP (total spectral power), LF and HF (power of the low- and high-frequency bands), LF norm and HF norm (LF and HF in normalized units), and LF/HF ratio of the HRV signal, obtained from 5-min-long ECG recordings during each phase of the test, were analyzed for subjects with the metabolic syndrome, marathon runners, and a control group. Results show that, after the glucose load, subjects with the metabolic syndrome experienced an increased sympathetic and decreased parasympathetic tone, which suggests an imbalance in cardiac autonomic modulation as a consequence of hyperglycemia and hyperinsulinemia. The significance of this study lies in the use of the ECG to assess the effects of a sudden increase in plasma glucose concentration on the cardiac autonomic modulation in subjects with different cardiovascular and metabolic conditions. Graphical Abstract Time-domain and frequency-domain heart rate variability measures are altered in subjects with different cardiovascular and metabolic conditions during an oral glucose tolerance test
URI: http://dspace.ucuenca.edu.ec/handle/123456789/33119
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055683043&origin=inward
metadata.dc.ucuenca.urifuente: https://info.sciverse.com/i.php?issn=0025-696X
ISSN: 0140-0118
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