Hiperuricemia asociada a complicaciones materno-fetales en pacientes con preeclampsia, Hospital Vicente Corral Moscoso, Cuenca, 2017

Abstract

Objective: To determine the association between hyperuricemia and maternal and fetal complications in women from 28 weeks of gestation, diagnosed of preeclampsia and hospitalized in the Department of Obstetrics of the Hospital Vicente Corral Moscoso, during the year 2017.

Materials and Methods: A cross-sectional study was carried out in a sample of 185 preeclamptic patients. The sample size was calculated with 95% confidence, 14% prevalence of HELLP syndrome, 5% inference error; the patients entered the study sequentially. The data were taken directly and analyzed with the SPSS software, version 15. The magnitude of the risk was performed with the prevalence ratio and its 95% confidence interval, and the significance with the Fisher exact test, correction of Yachts and the Chi square.

Results: Age fluctuated between 15 and 45 years, 42% lived in free union, 51% resided in urban areas; the number of gestas varied between 1 and 11; the termination of pregnancy was between 28 and 41 weeks, with cesarean section being the main route. The prevalence of hyperuricemia was 36.8% (95% CI: 29.9-43.5). A significant association of hyperuricemia with eclampsia (RP 2.83, 95% CI: 2.32-3.44 and corrected p-value 0.017), low weight (RP 2.28, 95% CI: 1.57-3.31 and p-value 0.000) and prematurity (RP 1.73, 95% CI: 1.17-2.57 and p-value 0.017).

Conclusions: The prevalence of hyperuricemia is lower than that found in other studies. High values of uric acid can predict the development of complications such as eclampsia, low birth weight and prematurity.