La interacción entre la exposición a agrotóxicos y componentes relevantes del sistema inmune en comunidades de La Paz Bolivia: una mirada desde la epidemiología crítica

Abstract

Health from critical epidemiology is a complex, dynamic and dialectic process, socially determined, with general, particular, and singular domains where unhealthy (destructive) processes and healthy (protective) processes are developed. Some authors point to an increase in the prevalence of diseases associated with alterations in the immune response, due to pesticides exposure, but this information in humans is limited and controversial. We intend to know the interaction between exposure to pesticides and components of the immune system: MPO and FAG phagocytic enzymes by cytochemistry and Interleukins 6 and 8 by chemiluminescence) in 5 communities of La Paz Bolivia, applying a questionnaire corresponding to critical epidemiology (matrix of processes) and work stress. Epidemiological profiles of 113 volunteers (farmers) were analyzed: 60 women and 53 men, finding significant differences (Chi-square): lifestyle typology (economic reproduction, pesticides use and secondary work), destructive processes, protective equipment, training, age. Observing decreased enzymatic activity MPO and increased FAG, for both genders of active working age. Without significance: interleukins and work stress. There is an affectation in the enzymatic functionality in cells of the first line of defense of the immune system and in the concentration ratio of interleukins, in farmers more or less exposed to pesticides considering their styles and ways of life.