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Title: Evaluation of anti-inflammatory activity of the methanolic extract from Jungia rugosa leaves in rodents
Other Titles: 
Authors: Wilches Arizabala, Isabel Maria
Tobar Solano, Vladimiro Alexis
Peñaherrera Wilches, Eugenia
Cuzco Quizhpi, Nancy Mirian
Jerves Andrade, Maria De lourdes
Vander Heyden, Yvan
Leon Tamariz, Fabian
Vila Calsina, Elisabet Null
Keywords: Inflammation
Jungia Rugosa
Traditional Medicine Meso-Southern America
metadata.dc.ucuenca.areaconocimientofrascatiamplio: 1. Ciencias Naturales y Exactas
metadata.dc.ucuenca.areaconocimientofrascatidetallado: 1.4.1 Química Orgánica
metadata.dc.ucuenca.areaconocimientofrascatiespecifico: 1.4 Ciencias Químicas
metadata.dc.ucuenca.areaconocimientounescoamplio: 05 - Ciencias Físicas, Ciencias Naturales, Matemáticas y Estadísticas
metadata.dc.ucuenca.areaconocimientounescodetallado: 0512 - Bioquímica
metadata.dc.ucuenca.areaconocimientounescoespecifico: 051 - Ciencias Biológicas y Afines
Issue Date: 2015
metadata.dc.ucuenca.volumen: Volumen 173
metadata.dc.source: Journal of Ethnopharmacology
metadata.dc.type: ARTÍCULO
Ethnopharmacological relevance: Jungia rugosa Less (Asteraceae), popularly known in Ecuador as "Carne humana" or "Fompo", is a vine present into the Andean region. It is traditionally used as medicine for the treatment of bruises, cuts and other external inflammatory processes. This study was designed to investigate the anti-inflammatory activity of J. rugosa leaves extract (JRLE) in rodents. Material and methods: The acute anti-inflammatory activity was evaluated by animal models, including croton oil-induced ear oedema in mice, carrageenan-induced paw oedema in rats and myeloperoxidase (MPO); the chronic anti-inflammatory activity was evaluated by cotton pellet-induced granuloma. Results: Intraperitoneal administration of JRLE (125, 250, 500 mg/kg) significantly (p<0.01-0.001) inhibited the croton oil-induced ear oedema and MPO activity in mice; the carrageenan-induced paw oedema in rats was significantly (p<0.05) reduced by 500 mg/kg. Repeated (6 days) administration of the extract to mice previously implanted with cotton pellets reduced the formed granuloma (125 mg/kg: 11.7%; 250 mg/kg: 17.9%; 500 mg/kg: 32.4%) but only the inhibition by 500 mg/kg reached statistical significance (p<0.01). Conclusions: The results show that JRLE is effective as an anti-inflammatory agent in acute and chronic inflammation in mice, supporting its traditional use. © 2015 Elsevier Ireland Ltd. All rights reserved.
Jungia rugosa Less (Asteraceae), conocida popularmente en Ecuador como "Carne humana" o "Fompo", es una enredadera presente en la región andina. Se usa tradicionalmente como medicina para el tratamiento de contusiones, cortes y otros procesos inflamatorios externos. Este estudio fue diseñado para investigar la actividad antiinflamatoria del extracto de hojas de J. rugosa (JRLE) en roedores.
URI: https://www.sciencedirect.com/science/article/pii/S0378874115300210?via%3Dihub
metadata.dc.ucuenca.urifuente: https://www.sciencedirect.com/journal/journal-of-ethnopharmacology/vol/173/suppl/C
ISSN: 1872-7573
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