Please use this identifier to cite or link to this item: http://dspace.ucuenca.edu.ec/handle/123456789/22152
Title: Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models
Authors: Orellana Paucar, Adriana Monserrath
Leon Tamariz, Fabián
Wilches Arizabala, Isabel María
Keywords: Ar-turmerone
Bisabolene sesquiterpenoids
Curcuma longa
Mouse PTZ model
Pentylenetetrazole
Turmeric
Turmeric oil
Zebrafish PTZ model
??-Turmerone
?-Atlantone
Issue Date: 1-May-2012
metadata.dc.ucuenca.embargoend: 1-Jan-2022
metadata.dc.type: Article
Abstract: 
Turmeric, obtained from the rhizomes of Curcuma longa, is used in South Asia as a traditional medicine for the treatment of epilepsy. To date, in vivo studies on the anticonvulsant activity of turmeric have focused on its principal curcuminoid, curcumin. However, poor absorption and rapid metabolism have limited the therapeutic application of curcumin in humans. To explore the therapeutic potential of turmeric for epilepsy further, we analyzed its anticonvulsant activity in a larval zebrafish seizure assay. Initial experiments revealed that the anticonvulsant activity of turmeric in zebrafish larvae cannot be explained solely by the effects of curcumin. Zebrafish bioassay-guided fractionation of turmeric identified bisabolene sesquiterpenoids as additional anticonvulsants that inhibit PTZ-induced seizures in both zebrafish and mice. Here, we present the first report of the anticonvulsant properties of bisabolene sesquiterpenoids and provide evidence which warrants further investigation toward the mechanistic understanding of their neuromodulatory activity. © 2012 Elsevier Inc.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-84860668697&doi=10.1016%2fj.yebeh.2012.02.020&partnerID=40&md5=0be666284143d519b0f120112689b6b0
http://dspace.ucuenca.edu.ec/handle/123456789/22152
ISSN: 15255050
Appears in Collections:Artículos

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