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DC Field | Value | Language |
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dc.contributor.author | Orellana Paucar, Adriana Monserrath | - |
dc.contributor.author | Afrikanova, Tatiana | - |
dc.contributor.author | Thomas, Joice | - |
dc.contributor.author | Aibuldinov, Yelaman K. | - |
dc.contributor.author | Dehaen, Wim | - |
dc.contributor.author | De Witte, Peter A.M. | - |
dc.contributor.author | Esguerra, Camila Vicencio | - |
dc.date.accessioned | 2018-01-11T21:21:49Z | - |
dc.date.available | 2018-01-11T21:21:49Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | e 1932-6203 | - |
dc.identifier.uri | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081634 | - |
dc.description.abstract | In a previous study, we uncovered the anticonvulsant properties of turmeric oil and its sesquiterpenoids (ar- turmerone, α-, β-turmerone and α-atlantone) in both zebrafish and mouse models of chemically-induced seizures using pentylenetetrazole (PTZ). In this follow-up study, we aimed at evaluating the anticonvulsant activity of ar- turmerone further. A more in-depth anticonvulsant evaluation of ar-turmerone was therefore carried out in the i.v. PTZ and 6-Hz mouse models. The potential toxic effects of ar-turmerone were evaluated using the beam walking test to assess mouse motor function and balance. In addition, determination of the concentration-time profile of ar- turmerone was carried out for a more extended evaluation of its bioavailability in the mouse brain. Ar-turmerone displayed anticonvulsant properties in both acute seizure models in mice and modulated the expression patterns of two seizure-related genes (c-fos and brain-derived neurotrophic factor [bdnf]) in zebrafish. Importantly, no effects on motor function and balance were observed in mice after treatment with ar-turmerone even after administering a dose 500-fold higher than the effective dose in the 6-Hz model. In addition, quantification of its concentration in mouse brains revealed rapid absorption after i.p. administration, capacity to cross the BBB and long-term brain residence. Hence, our results provide additional information on the anticonvulsant properties of ar-turmerone and support further evaluation towards elucidating its mechanism of action, bioavailability, toxicity and potential clinical application. | - |
dc.language.iso | es_ES | - |
dc.source | Plos One | - |
dc.subject | Mouse models | - |
dc.subject | Anticonvulsants | - |
dc.subject | Zebrafish | - |
dc.subject | Oils | - |
dc.subject | Epilepsy | - |
dc.subject | Mice | - |
dc.subject | Larvae | - |
dc.title | Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy | - |
dc.type | ARTÍCULO | - |
dc.ucuenca.idautor | 0103903142 | - |
dc.ucuenca.idautor | Srgp-4724-02 | - |
dc.ucuenca.idautor | 0000-0001-5517-4663 | - |
dc.ucuenca.idautor | 0000-0001-9143-4581 | - |
dc.ucuenca.idautor | 0000-0002-9597-0629 | - |
dc.ucuenca.idautor | 0000-0002-9989-9567 | - |
dc.ucuenca.idautor | 0000-0002-2271-8094 | - |
dc.identifier.doi | 10.1371/journal.pone.0081634 | - |
dc.ucuenca.version | Versión publicada | - |
dc.ucuenca.areaconocimientounescoamplio | 09 - Salud y Bienestar | - |
dc.ucuenca.afiliacion | Orellana, A., Universidad de Cuenca, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Afrikanova, T., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Thomas, J., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Aibuldinov, Y., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Dehaen, W., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | De Witte, P., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Esguerra, C., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.volumen | Volumen 8, número 12 | - |
dc.ucuenca.indicebibliografico | SCOPUS | - |
dc.ucuenca.factorimpacto | 0.99 | - |
dc.ucuenca.cuartil | Q1 | - |
dc.ucuenca.numerocitaciones | 0 | - |
dc.ucuenca.areaconocimientofrascatiamplio | 3. Ciencias Médicas y de la Salud | - |
dc.ucuenca.areaconocimientofrascatiespecifico | 3.1 Medicina Básica | - |
dc.ucuenca.areaconocimientofrascatidetallado | 3.1.5 Farmacología y Farmacia | - |
dc.ucuenca.areaconocimientounescoespecifico | 091 - Salud | - |
dc.ucuenca.areaconocimientounescodetallado | 0916 - Farmacia | - |
dc.ucuenca.urifuente | https://journals.plos.org/plosone/search?q=Insights+from+Zebrafish+and+Mouse+Models+on+the+Activity+and+Safety+of+Ar-Turmerone+&filterJournals=PLoSONE | - |
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documento.pdf | document | 1.23 MB | Adobe PDF | View/Open |
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