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DC Field | Value | Language |
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dc.contributor.author | Buenafe, Olivia Erin | - |
dc.contributor.author | Orellana Paucar, Adriana Monserrath | - |
dc.contributor.author | Maes, Jan | - |
dc.contributor.author | Huang, Hao | - |
dc.contributor.author | Ying, Xuhui | - |
dc.contributor.author | De Borggraeve, Wim | - |
dc.contributor.author | Crawford, Alexander D. | - |
dc.contributor.author | Luyten, Walter | - |
dc.contributor.author | Esguerra, Camila Vicencio | - |
dc.contributor.author | De Witte, Peter A.M. | - |
dc.date.accessioned | 2018-01-11T21:21:53Z | - |
dc.date.available | 2018-01-11T21:21:53Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 19487193 | - |
dc.identifier.uri | https://pubs.acs.org/doi/10.1021/cn400140e | - |
dc.description.abstract | Danshen or Chinese red sage (Salvia miltiorrhiza, Bunge) is used by traditional Chinese medicine (TCM) practitioners to treat neurological, cardiovascular, and cerebrovas- cular disorders and is included in some TCM formulations to control epileptic seizures. In this study, acetonic crude extracts of danshen inhibited pentylenetetrazol (PTZ)-induced seizure activity in zebrafish larvae. Subsequent zebrafish bioassay-guided fractio- nation of the extract resulted in the isolation of four major tanshinones, which suppressed PTZ-induced activity to varying degrees. One of the active tanshinones, tanshinone IIA, also reduced c-fos expression in the brains of PTZ-exposed zebrafish larvae. In rodent seizure models, tanshinone IIA showed anticonvulsive activity in the mouse 6-Hz psychomotor seizure test in a biphasic manner and modified seizure thresholds in a complex manner for the mouse i.v. PTZ seizure assay. Interestingly, tanshinone IIA is used as a prescription drug in China to address cerebral ischemia in patients. Here, we provide the first in vivo evidence demonstrating that tanshinone IIA has anticonvulsant properties as well. | - |
dc.language.iso | es_ES | - |
dc.source | ACS Chemical Neuroscience | - |
dc.subject | Tanshinone IIA | - |
dc.subject | Salvia miltiorrhiza | - |
dc.subject | Zebrafish PTZ model | - |
dc.subject | Mouse seizure models | - |
dc.subject | Pentylenetetrazol | - |
dc.title | Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models | - |
dc.type | ARTÍCULO | - |
dc.ucuenca.idautor | 0000-0001-6048-4121 | - |
dc.ucuenca.idautor | 0103903142 | - |
dc.ucuenca.idautor | 0000-0002-3422-8615 | - |
dc.ucuenca.idautor | 0000-0002-7788-5519 | - |
dc.ucuenca.idautor | 0000-0002-3063-9062 | - |
dc.ucuenca.idautor | 0000-0001-7813-6192 | - |
dc.ucuenca.idautor | Srgp-4722-07 | - |
dc.ucuenca.idautor | 0000-0002-3302-5816 | - |
dc.ucuenca.idautor | 0000-0002-2271-8094 | - |
dc.ucuenca.idautor | 0000-0002-9989-9567 | - |
dc.identifier.doi | 10.1021/cn400140e | - |
dc.ucuenca.version | Versión publicada | - |
dc.ucuenca.areaconocimientounescoamplio | 09 - Salud y Bienestar | - |
dc.ucuenca.afiliacion | Buenafe, O., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Orellana, A., Universidad de Cuenca, Cuenca, Ecuador | - |
dc.ucuenca.afiliacion | Maes, J., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Huang, H., Gannan Medical University, Ganzhou, China | - |
dc.ucuenca.afiliacion | Ying, X., Nankai University, Tianjin, China | - |
dc.ucuenca.afiliacion | De Borggraeve, W., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Crawford, A., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Luyten, W., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.afiliacion | Esguerra, C., Nankai University, Tianjin, China | - |
dc.ucuenca.afiliacion | De Witte, P., KU Leuven (Katholieke Universiteit Leuven), Leuven, Belgica | - |
dc.ucuenca.volumen | Volumen 4, número 11 | - |
dc.ucuenca.indicebibliografico | SCOPUS | - |
dc.ucuenca.factorimpacto | 1.158 | - |
dc.ucuenca.cuartil | Q1 | - |
dc.ucuenca.numerocitaciones | 0 | - |
dc.ucuenca.areaconocimientofrascatiamplio | 3. Ciencias Médicas y de la Salud | - |
dc.ucuenca.areaconocimientofrascatiespecifico | 3.1 Medicina Básica | - |
dc.ucuenca.areaconocimientofrascatidetallado | 3.1.5 Farmacología y Farmacia | - |
dc.ucuenca.areaconocimientounescoespecifico | 091 - Salud | - |
dc.ucuenca.areaconocimientounescodetallado | 0916 - Farmacia | - |
dc.ucuenca.urifuente | https://pubs.acs.org/toc/acncdm/4/11 | - |
Appears in Collections: | Artículos |
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